Background Interleukin-12 (IL-12) is a macrophage-derived cytokine that modulates T
lymphocyte responses and has the capacity to suppress allergic and eosinophilic inflammation. …

Background To address the unmet medical need for an effective prophylactic vaccine
against Ebola virus we assessed the safety and immunogenicity of three different two-dose …

Advancement of RNAi-based therapeutics depends on effective delivery to the site of protein
synthesis. Although intravenously administered, multi-component delivery vehicles have …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Domperidone, a dopamine antagonist
metabolized mainly by CYP3A, has been used as an anti‐emetic and prokinetic agent by …

Aims Netazepide, a gastrin/cholecystokinin 2 receptor antagonist, once daily for 12 weeks
reduced the number of tumours and size of the largest one in 16 patients with autoimmune …

Objective The incidence of esophageal adenocarcinoma (EAC) is increasing, but factors
contributing to malignant progression of its precursor lesion, Barrett's esophagus (BE), have not …

Introduction Autoimmune chronic atrophic gastritis (CAG) causes hypochlorhydria and
hypergastrinaemia, which can lead to enterochromaffin-like (ECL) cell hyperplasia and gastric …

Aims Cathepsin C (CTSC) is necessary for the activation of several serine proteases
including neutrophil elastase (NE), cathepsin G and proteinase 3. GSK2793660 is an oral, …

Background Interleukin-13 (IL-13) is a key mediator of T-helper-cell-type-2 (Th-2)-driven
asthma, the inhibition of which may improve treatment outcomes. We examined the safety, …

Aims To compare the pharmacokinetics, safety, tolerability and immunogenicity of FKB327,
a biosimilar of adalimumab, with European Union (EU)‐approved Humira and US‐licensed …