User profiles for Magdalena Wysocka

Magdalena Wysocka

- Verified email at ug.edu.pl - Cited by 1209

Magdalena Wysocka

- Verified email at cruk.manchester.ac.uk - Cited by 167

[HTML][HTML] Fecal serine protease profiling in inflammatory bowel diseases

…, N Akermi, S Soussou, M Wysocka… - Frontiers in cellular …, 2020 - frontiersin.org
Serine proteases are extensively known to play key roles in many physiological processes.
However, their dysregulation is often associated to several diseases including inflammatory …

Substrate profiling of Zika virus NS 2B‐NS 3 protease

…, JI Rodriguez Martinez, R Grzywa, M Wysocka… - FEBS …, 2016 - Wiley Online Library
Zika virus ( ZIKV ), isolated from macaques in Uganda in 1947, was not considered to be a
dangerous human pathogen. However, this view has recently changed as ZIKV infections are …

[HTML][HTML] Antibiotic resistance, virulence, and phylogenetic analysis of Escherichia coli strains isolated from free-living birds in human habitats

…, B Krawczyk, B Furmanek-Blaszk, M Wysocka… - PLoS …, 2022 - journals.plos.org
Wild birds can be colonized by bacteria, which are often resistant to antibiotics and have
various virulence profiles. The aim of this study was to analyze antibiotic resistance …

Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery

A Lesner, A Legowska, M Wysocka… - Current pharmaceutical …, 2011 - ingentaconnect.com
This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14
amino acid cyclic peptide exhibits several features ie compact rigidity, well-defined structure …

[HTML][HTML] Meta-analysis informed machine learning: Supporting cytokine storm detection during CAR-T cell Therapy

A Bogatu, M Wysocka, O Wysocki, H Butterworth… - Journal of Biomedical …, 2023 - Elsevier
Cytokine release syndrome (CRS), also known as cytokine storm, is one of the most
consequential adverse effects of chimeric antigen receptor therapies that have shown otherwise …

[PDF][PDF] Rola lekarzy niestomatologów w zapobieganiu próchnicy wczesnego dzieciństwa

S Janus, D Olczak-Kowalczyk, M Wysocka - Nowa Pediatr, 2011 - ppm.edu.pl
Presented paper gives a definition of the early childhood caries, accompanied by epidemiological
data. it describes main rules of preventive work, including actions undertaken as early …

[HTML][HTML] Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus

M Zdzalik, M Kalinska, M Wysocka, J Stec-Niemczyk… - PLoS …, 2013 - journals.plos.org
Staphylococcus aureus is a dangerous human pathogen. A number of the proteins secreted
by this bacterium are implicated in its virulence, but many of the components of its …

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors

A Łęgowska, D Dębowski, A Lesner, M Wysocka… - Bioorganic & medicinal …, 2009 - Elsevier
A series of trypsin inhibitor SFTI-1compounds modified in substrate-specific P 1 position was
synthesized by the solid-phase method. Lys5 present in the wild inhibitor was replaced by …

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

B Korkmaz, A Lesner, M Wysocka, A Gieldon… - Biochemical …, 2019 - Elsevier
Cathepsin C (CatC) is a dipeptidyl-exopeptidase which activates neutrophil serine protease
precursors (elastase, proteinase 3, cathepsin G and NSP4) by removing their N-terminal …

Large language models, scientific knowledge and factuality: A systematic analysis in antibiotic discovery

M Wysocka, O Wysocki, M Delmas, V Mutel… - arXiv preprint arXiv …, 2023 - arxiv.org
Inferring over and extracting information from Large Language Models (LLMs) trained on a
large corpus of scientific literature can potentially drive a new era in biomedical research, …