The causes of severe childhood asthma are poorly understood. Our aim was to define global
patterns of gene expression in children with severe therapy-resistant and controlled asthma…

Asthma is highly prevalent, often starting in infancy and persisting throughout life, and is
associated with high morbidity and burden. It is a major global health challenge with growing …

Rationale: Frequent exacerbations are a poor prognostic sign in asthma. There are few
studies on exacerbations that have followed patients with repeated objective measures over …

Background: A frequent–exacerbation phenotype of chronic obstructive pulmonary disease (COPD)
has been reported but has not yet been clearly defined. Aim: To characterize and …

Biomarkers able to determine responsiveness to therapy in severe asthma (SA) are needed.
Our goal was to examine the usefulness of periostin, eosinophils and exhaled NO as …

METHODS BIOAIR (Longitudinal Assessment of Clinical Course and BIOmarkers in severe
Chronic AIRway Disease) is a European multicentre study including patients with severe and …

Results: Etoricoxib treatment did not change pre-challenge baseline lung function (mean±SEM
FEV 3.78±0.20 and 3.82±0.20 after 1 drug and control, respectively), AHR to MCh (Fig 1) …

RATIONALE Neuropeptide S receptor 1 () is a strong candidate gene for asthma. Previous
data suggest that environmental factors such as farm NPSR1 exposure can modulate genetic …

Background: Allergic reactions are common in laboratory animal workers and one of four
individuals working with laboratory animals report work-related allergic symptoms and may …

Aim: Serum periostin levels were measured by ELISA using 2 rat anti-human periostin mAbs
(clones SS18A and SS17B), as described Methods: previously (Okamoto et al. ERJ 2011; …