Improved survival among HIV-infected individuals following initiation of antiretroviral therapy

…, KV Heath, B Yip, KJP Craib, MV O'shaughnessy… - Jama, 1998 - jamanetwork.com
Context.—Clinical trials have established the efficacy of antiretroviral therapy with double-
and triple-drug regimens for individuals infected with the human immunodeficiency virus (HIV)…

Rates of disease progression by baseline CD4 cell count and viral load after initiating triple-drug therapy

…, KJ Chan, E Wood, KJP Craib, MV O'Shaughnessy… - Jama, 2001 - jamanetwork.com
ContextCurrent recommendations for initiation of antiretroviral therapy in patients infected
with human immunodeficiency virus type 1 (HIV) are based on CD4 T-lymphocyte cell counts …

Industry-sponsored clinical research: a double-edged sword

JSG Montaner, MV O'Shaughnessy, MT Schechter - The Lancet, 2001 - thelancet.com
Drug development has accelerated exponentially since the 1950s. It is difficult to estimate the
relative contributions or rates of success of industry sponsored as opposed to government …

Needle exchange is not enough: lessons from the Vancouver injecting drug use study

…, JSG Montaner, MT Schechter, MV O'Shaughnessy - Aids, 1997 - journals.lww.com
Objective: To describe prevalence and incidence of HIV-1, hepatitis C virus (HCV) and risk
behaviours in a prospective cohort of injecting drug users (IDU). Setting: Vancouver, which …

[HTML][HTML] Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients

…, PR Harrigan, MV O'Shaughnessy… - … England Journal of …, 2002 - Mass Medical Soc
Background Nucleoside analogues can induce toxic effects on mitochondria by inhibiting the
human DNA polymerase γ. The toxic effects can range from increased serum lactate levels …

Barriers to use of free antiretroviral therapy in injection drug users

…, A Palepu, PGA Cornelisse, B Yip, MV O'Shaughnessy… - Jama, 1998 - jamanetwork.com
Context.—In British Columbia, human immunodeficiency virus (HIV)–infected persons eligible
for antiretroviral therapy may receive it free but the extent to which HIV-infected injection …

Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up

…, D Bangsberg, B Yip, N Press, MV O'Shaughnessy… - Aids, 2002 - journals.lww.com
Results As of 30 September 2000, 106 subjects had died. Cumulative mortality was 3.9%(±0.5%)
at 12 months. In a multivariate model, after controlling for other variables that were …

Effect of Medication Adherence on Survival of HIV-Infected Adults Who Start Highly Active Antiretroviral Therapy When the CD4+ Cell Count Is 0.200 to 0.350 × 109 …

…, B Yip, PR Harrigan, MV O'Shaughnessy… - Annals of internal …, 2003 - acpjournals.org
Background: The safety of delaying highly active antiretroviral therapy (HAART) in HIV-infected
patients is uncertain when the CD4+ cell count declines below 0.350 × 10 9 cells/L. …

Intensive injection cocaine use as the primary risk factor in the Vancouver HIV-1 epidemic

…, S Currie, P Spittal, K Li, E Wood, MV O'Shaughnessy… - Aids, 2003 - journals.lww.com
Objectives: The explosive and ongoing injecting drug use-related HIV-1 epidemic in Vancouver
continues to receive international attention. This study was conducted to determine how …

Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens

…, B Yip, C Kully, KJP Craib, MV O'Shaughnessy… - Cmaj, 1999 - Can Med Assoc
BACKGROUND: The efficacy of triple-drug antiretroviral regimens in the treatment of patients
infected with HIV has been established in several randomized clinical trials. However, the …