User profiles for M.J. Ratcliffe
Matthew RatcliffeProfessor of Philosophy, University of York Verified email at york.ac.uk Cited by 7161 |
[HTML][HTML] “Interchangeability” of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy
…, D Ionescu, C Li, E Munari, K Okuda, MJ Ratcliffe… - Modern Pathology, 2020 - Elsevier
Different clones, protocol conditions, instruments, and scoring/readout methods may pose
challenges in introducing different PD-L1 assays for immunotherapy. The diagnostic accuracy …
challenges in introducing different PD-L1 assays for immunotherapy. The diagnostic accuracy …
Agreement between programmed cell death ligand-1 diagnostic assays across multiple protein expression cutoffs in non–small cell lung cancer
MJ Ratcliffe, A Sharpe, A Midha, C Barker, M Scott… - Clinical cancer …, 2017 - AACR
… MJ Ratcliffe and M. Scott hold ownership interest (including patents) in AstraZeneca. No
potential … Writing, review, and/or revision of the manuscript: MJ Ratcliffe, A. Sharpe, A. Midha, C. …
potential … Writing, review, and/or revision of the manuscript: MJ Ratcliffe, A. Sharpe, A. Midha, C. …
[HTML][HTML] Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
K Itoh, BK Brott, GU Bae, MJ Ratcliffe, SY Sokol - Journal of biology, 2005 - Springer
Background Dishevelled (Dsh) is a key component of multiple signaling pathways that are
initiated by Wnt secreted ligands and Frizzled receptors during embryonic development. …
initiated by Wnt secreted ligands and Frizzled receptors during embryonic development. …
[HTML][HTML] A positive role for the PP2A catalytic subunit in Wnt signal transduction
MJ Ratcliffe, K Itoh, SY Sokol - Journal of Biological Chemistry, 2000 - ASBMB
Protein phosphatase-2A (PP2A) is a multisubunit serine/threonine phosphatase involved in
intracellular signaling, gene regulation, and cell cycle progression. Different subunits of …
intracellular signaling, gene regulation, and cell cycle progression. Different subunits of …
[HTML][HTML] CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans
…, MA Kachura, JA Lum, MJ Ratcliffe… - The Journal of …, 2009 - Am Soc Clin Investig
CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are
being developed as a therapy for allergic indications and have proven to be safe and well …
being developed as a therapy for allergic indications and have proven to be safe and well …
Identification and analysis of the expression of CD8 alpha beta and CD8 alpha alpha isoforms in chickens reveals a major TCR-gamma delta CD8 alpha beta subset …
…, E Paramithiotis, CL Chen, MJ Ratcliffe… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
Expression screening has been used to clone cDNAs encoding the alpha- and beta-chains
of chicken CD8. Amino acid sequence similarities with the mammalian sequences were …
of chicken CD8. Amino acid sequence similarities with the mammalian sequences were …
Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction
K Itoh, A Antipova, MJ Ratcliffe… - Molecular and Cellular …, 2000 - Taylor & Francis
Signaling by the Wnt family of secreted proteins plays an important role in animal development
and is often misregulated in carcinogenesis. Wnt signal transduction is controlled by the …
and is often misregulated in carcinogenesis. Wnt signal transduction is controlled by the …
Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-α release from human alveolar macrophages
MJ Ratcliffe, A Walding, PA Shelton… - European …, 2007 - Eur Respiratory Soc
Prostaglandin (PG)E 2 has been shown to inhibit mediator release from human alveolar
macrophages (AMs), but the prostanoid receptor(s) mediating this response have not yet been …
macrophages (AMs), but the prostanoid receptor(s) mediating this response have not yet been …
[HTML][HTML] Impact of Decalcification, Cold Ischemia, and Deglycosylation on Performance of Programmed Cell Death Ligand-1 Antibodies With Different Binding …
…, GH Williams, ME Vandenberghe, MJ Ratcliffe… - Modern Pathology, 2023 - Elsevier
Programmed cell death ligand-1 (PD-L1) expression levels in patients’ tumors have demonstrated
clinical utility across many cancer types and are used to determine treatment eligibility…
clinical utility across many cancer types and are used to determine treatment eligibility…
[HTML][HTML] Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay
P Scorer, M Scott, N Lawson, MJ Ratcliffe, C Barker… - Diagnostic …, 2018 - Springer
Background Several anti-programmed cell death-1 (PD-1) and anti-programmed cell death
ligand-1 (PD-L1) therapies have shown encouraging safety and clinical activity in a variety of …
ligand-1 (PD-L1) therapies have shown encouraging safety and clinical activity in a variety of …