User profiles for M.J. Ratcliffe

Matthew Ratcliffe

Professor of Philosophy, University of York
Verified email at york.ac.uk
Cited by 7161

[HTML][HTML] “Interchangeability” of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy

…, D Ionescu, C Li, E Munari, K Okuda, MJ Ratcliffe… - Modern Pathology, 2020 - Elsevier
Different clones, protocol conditions, instruments, and scoring/readout methods may pose
challenges in introducing different PD-L1 assays for immunotherapy. The diagnostic accuracy …

Agreement between programmed cell death ligand-1 diagnostic assays across multiple protein expression cutoffs in non–small cell lung cancer

MJ Ratcliffe, A Sharpe, A Midha, C Barker, M Scott… - Clinical cancer …, 2017 - AACR
MJ Ratcliffe and M. Scott hold ownership interest (including patents) in AstraZeneca. No
potential … Writing, review, and/or revision of the manuscript: MJ Ratcliffe, A. Sharpe, A. Midha, C. …

[HTML][HTML] Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

K Itoh, BK Brott, GU Bae, MJ Ratcliffe, SY Sokol - Journal of biology, 2005 - Springer
Background Dishevelled (Dsh) is a key component of multiple signaling pathways that are
initiated by Wnt secreted ligands and Frizzled receptors during embryonic development. …

[HTML][HTML] A positive role for the PP2A catalytic subunit in Wnt signal transduction

MJ Ratcliffe, K Itoh, SY Sokol - Journal of Biological Chemistry, 2000 - ASBMB
Protein phosphatase-2A (PP2A) is a multisubunit serine/threonine phosphatase involved in
intracellular signaling, gene regulation, and cell cycle progression. Different subunits of …

[HTML][HTML] CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

…, MA Kachura, JA Lum, MJ Ratcliffe… - The Journal of …, 2009 - Am Soc Clin Investig
CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are
being developed as a therapy for allergic indications and have proven to be safe and well …

Identification and analysis of the expression of CD8 alpha beta and CD8 alpha alpha isoforms in chickens reveals a major TCR-gamma delta CD8 alpha beta subset …

…, E Paramithiotis, CL Chen, MJ Ratcliffe… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
Expression screening has been used to clone cDNAs encoding the alpha- and beta-chains
of chicken CD8. Amino acid sequence similarities with the mammalian sequences were …

Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction

K Itoh, A Antipova, MJ Ratcliffe… - Molecular and Cellular …, 2000 - Taylor & Francis
Signaling by the Wnt family of secreted proteins plays an important role in animal development
and is often misregulated in carcinogenesis. Wnt signal transduction is controlled by the …

Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-α release from human alveolar macrophages

MJ Ratcliffe, A Walding, PA Shelton… - European …, 2007 - Eur Respiratory Soc
Prostaglandin (PG)E 2 has been shown to inhibit mediator release from human alveolar
macrophages (AMs), but the prostanoid receptor(s) mediating this response have not yet been …

[HTML][HTML] Impact of Decalcification, Cold Ischemia, and Deglycosylation on Performance of Programmed Cell Death Ligand-1 Antibodies With Different Binding …

…, GH Williams, ME Vandenberghe, MJ Ratcliffe… - Modern Pathology, 2023 - Elsevier
Programmed cell death ligand-1 (PD-L1) expression levels in patients’ tumors have demonstrated
clinical utility across many cancer types and are used to determine treatment eligibility…

[HTML][HTML] Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay

P Scorer, M Scott, N Lawson, MJ Ratcliffe, C Barker… - Diagnostic …, 2018 - Springer
Background Several anti-programmed cell death-1 (PD-1) and anti-programmed cell death
ligand-1 (PD-L1) therapies have shown encouraging safety and clinical activity in a variety of …