Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor
and arousal. During torpor, markedly reduced metabolic activity results in inactivity and …

Hypothermia and rewarming produces organ injury through the production of reactive
oxygen species. We previously found that dopamine prevents hypothermia and rewarming-…

Background Mitochondrial dysfunction plays an important role in kidney damage in various
pathologies, including acute and chronic kidney injury and diabetic nephropathy. In addition …

To study the value of 4-aminopyridine as an antidote to verapamil intoxication, we subjected
12 adult cats to verapamil poisoning by administering doses of 4.0-25.0 mg/kg verapamil by …

Background The incidence of acute kidney injury following severe sepsis is higher in the
elderly. We hypothesized that microvascular endothelium is "primed" by aging and that sepsis …

Erythropoietin (EPO) mobilises endothelial progenitor cells and promotes neovascularisation
in heart failure. The present authors studied the effects of EPO on pulmonary vascular and …

Introduction The interaction between neutrophils and activated endothelium is essential for
the development of multiple organ dysfunction in patients with hemorrhagic shock (HS). …

INTRODUCTION: Rat models of cardiopulmonary bypass (CPB) have been used to examine
the mechanisms of associated organ damage and to test intervention strategies. However, …

Background Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular
dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and immune …

The neuromuscular and cardiovascular activities of pancuronium were compared with those
of its 16β monoquaternary congener, Org NC 45, in the anaesthetized rat, cat and rhesus …