Persistent improvement of gas exchange and lung mechanics by aerosolized perfluorocarbon

MA Kandler, K von der HARDT, E Schoof… - American journal of …, 2001 - atsjournals.org
The effect of aerosolized perfluorocarbon (PFC) (FC77) on pulmonary gas exchange and lung
mechanics was studied in a surfactant depleted piglet model. Sixty minutes after induction …

[HTML][HTML] High frequency oscillatory ventilation suppresses inflammatory response in lung tissue and microdissected alveolar macrophages in surfactant depleted …

K von der Hardt, MA Kandler, L Fink, E Schoof… - Pediatric …, 2004 - nature.com
The impact of high frequency oscillatory ventilation (HFOV) compared with intermittent mandatory
ventilation (IMV) on oxygenation and pulmonary inflammatory response was studied in …

[HTML][HTML] Aerosolized perfluorocarbon suppresses early pulmonary inflammatory response in a surfactant-depleted piglet model

K Von Der Hardt, E Schoof, MA Kandler, J Dötsch… - Pediatric …, 2002 - nature.com
The effect of new ventilation strategies on initial pulmonary inflammatory reaction was
studied in a surfactant-depleted piglet model. Sixty minutes after induction of lung injury by …

Comparison of aerosol therapy with different perfluorocarbons in surfactant-depleted animals

K von der Hardt, MA Kandler, G Brenn… - Critical care …, 2004 - journals.lww.com
Objective: The study investigates the effectiveness of aerosol treatment on gas exchange and
pulmonary inflammatory reaction using perfluorocarbons with different molecular structure …

Hematopoietic stem cell transplantation and subsequent 80% skin exchange by grafts from the same donor in a patient with Herlitz disease

…, RE Horch, KD Stachel, W Holter, MA Kandler… - …, 2005 - journals.lww.com
The study by Kazory et al.(1) regarding the increased risk of venous thromboembolism (VTE)
in renal transplant recipients with cytomegalovirus (CMV) infection was interesting. The …

Laser-assisted microdissection and real-time PCR detect anti-inflammatory effect of perfluorocarbon

K von der Hardt, MA Kandler, L Fink… - … of Physiology-Lung …, 2003 - journals.physiology.org
The aim of this study was to identify cell types involved in the anti-inflammatory effect of
ventilation with perfluorocarbon in vivo. Fifteen anesthetized, surfactant-depleted piglets received …

Pilot intervention: aerosolized adrenomedullin reduces pulmonary hypertension

MA Kandler, K Von Der Hardt, S Mahfoud… - … of Pharmacology and …, 2003 - ASPET
In pulmonary hypertension, systemic infusion of adrenomedullin (ADM), a potent vasodilator
peptide, leads to pulmonary vasodilatation. However, systemic blood pressure declines …

Aerosolized perfluorocarbon reduces adhesion molecule gene expression and neutrophil sequestration in acute respiratory distress

E Schoof, K von der Hardt, MA Kandler… - European journal of …, 2002 - Elsevier
In acute respiratory distress syndrome, neutrophil migration into the lung plays a key role in
the development of lung injury. To study the effect of different modes of ventilation with …

Anakinra (IL‐1R antagonist) lowers pulmonary artery pressure in a neonatal surfactant depleted piglet model

…, J Dötsch, W Rascher, MA Kandler - Pediatric …, 2008 - Wiley Online Library
… von der Hardt K, Schoof E, Kandler MA, Dötsch J, Rascher W. Aerosolized perfluorocarbon
… Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced …

[HTML][HTML] Dose response to aerosolized perflubron in a neonatal swine model of lung injury

MA Kandler, K von der Hardt, N Gericke, M Chada… - Pediatric …, 2004 - nature.com
Aerosolized perfluorocarbon (PFC) improves gas exchange, lung mechanics, and pulmonary
artery pressure. The objective of this intervention was to study the dose-response effect to …