User profiles for M. Zignol

Matteo Zignol

Unit Head, Global Tuberculosis Programme, World Health Organization
Verified email at who.int
Cited by 29040

Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis

…, WW Yew, JJ Yim, NM Zetola, M Zignol… - The Lancet, 2018 - thelancet.com
Background Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed
to estimate the association of treatment success and death with the use of individual drugs, …

Epidemiology of antituberculosis drug resistance 2002–07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance

A Wright, M Zignol, A Van Deun, D Falzon, SR Gerdes… - The Lancet, 2009 - thelancet.com
Background The Global Project on Anti-Tuberculosis Drug Resistance has been gathering
data since 1994. This study provides the latest data on the extent of drug resistance worldwide…

[HTML][HTML] Drug-resistant tuberculosis: time for visionary political leadership

…, M Zignol, D Falzon, M Raviglione… - The Lancet infectious …, 2013 - thelancet.com
… Inappropriate monotherapy and intermittent treatment are the main causes of drug resistance,
and facilitate the selection and transmission of resistant strains of M tuberculosis within …

WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update

…, JL Walson, F Wares, K Weyer, RA White, M Zignol - 2011 - Eur Respiratory Soc
The production of guidelines for the management of drug-resistant tuberculosis (TB) fits the
mandate of the World Health Organization (WHO) to support countries in the reinforcement of …

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

NR Gandhi, P Nunn, K Dheda, HS Schaaf, M Zignol… - The Lancet, 2010 - thelancet.com
Although progress has been made to reduce global incidence of drug-susceptible
tuberculosis, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) …

Global incidence of multidrug-resistant tuberculosis

M Zignol, MS Hosseini, A Wright… - The Journal of …, 2006 - academic.oup.com
BackgroundThe global number of incident cases of multidrug-resistant (MDR) tuberculosis (TB)
in 2000 was estimated to be 272,906 (95% confidence interval [CI], 184,948–414,295). …

[HTML][HTML] The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis

…, M Mihalic, M WILCOX, M ZIGNOL, M Merker… - The Lancet …, 2022 - thelancet.com
Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC…

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

…, D Hanna, PS Kim, R Liwski, M Zignol… - European …, 2017 - Eur Respiratory Soc
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
is required to accelerate the development of rapid drug susceptibility testing methods …

A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: Application to Mycobacterium tuberculosis

G Lamichhane, M Zignol, NJ Blades… - Proceedings of the …, 2003 - National Acad Sciences
We describe a postgenomic in silico approach for identifying genes that are likely to be
essential and estimate their proportion in haploid genomes. With the knowledge of all sites …

Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF

…, W Van Gemert, L D'Ambrosio, M Zignol… - European …, 2013 - Eur Respiratory Soc
If tuberculosis (TB) is to be eliminated as a global health problem in the foreseeable future,
improved detection of patients, earlier diagnosis and timely identification of rifampicin …