From yeast to mammals, autophagy is an important mechanism for sustaining cellular
homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. …

Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of patients …

Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer (NSCLC)
leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …

The self-renewing epithelium of the small intestine is ordered into stem/progenitor crypt
compartments and differentiated villus compartments. Recent evidence indicates that the Wnt …

… The PCR mix consisted of 0.5 μm primers, 100 μm dNTPs, 9% glycerol, 2.5 units of Taq
polymerase, and 1× PCR buffer (GIBCO BRL) in a 20-μl volume. A hot start was performed using …

MYOTONIC dystrophy is a common dominant disorder (global incidence of 1:8,000) with
variable onset and a protean nature of symptoms mainly involving progressive muscle wasting, …

The use of Cre/loxP recombination in mammalian cells has expanded rapidly. We describe
here that Cre expression in cultured mammalian cells may result in a markedly reduced …

Conditional gene inactivation using the Cre/loxP system is widely used, but the difficulty in
properly regulating Cre expression remains one of the bottlenecks. One approach to regulate …

γ-Secretases are a family of intramembrane-cleaving proteases involved in various signaling
pathways and diseases, including Alzheimer's disease (AD). Cells co-express differing γ-…

Notch signaling is controlled by ligand binding, which unfolds a negative control region to
induce proteolytic cleavage of the receptor. First, a membrane-proximal cleavage is executed …