Animal models of ischemic stroke and their application in clinical research

F Fluri, MK Schuhmann… - Drug design, development …, 2015 - Taylor & Francis
This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is not …

Driver mutations in histone H3. 3 and chromatin remodelling genes in paediatric glioblastoma

…, A Klekner, L Bognar, M Ebinger, MU Schuhmann… - Nature, 2012 - nature.com
Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However,
DNA copy number and gene expression signatures indicate differences between adult and …

[HTML][HTML] Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

…, K Jacob, M Wolter, M Ebinger, MU Schuhmann… - Cancer cell, 2012 - cell.com
Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable
heterogeneity. We have recently identified recurrent H3F3A mutations affecting two …

[HTML][HTML] Spectrum of gluten-related disorders: consensus on new nomenclature and classification

…, K Kaukinen, K Rostami, DS Sanders, M Schumann… - BMC medicine, 2012 - Springer
… progressive ataxia evaluated over a period of 15 years in Sheffield, UK, found that 148 out
of 635 patients (23%) with sporadic ataxia had serological evidence of gluten sensitization (M. …

[HTML][HTML] The whole-genome landscape of medulloblastoma subtypes

…, C Herold-Mende, M Schuhmann, M Ebinger… - Nature, 2017 - nature.com
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

[HTML][HTML] Dissecting the genomic complexity underlying medulloblastoma

…, E Maass, J Rössler, M Ebinger, MU Schuhmann… - Nature, 2012 - nature.com
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain
stem. It is the most common malignant brain tumour in children, and shows tremendous …

[PDF][PDF] New brain tumor entities emerge from molecular classification of CNS-PNETs

…, M Wolter, MU Schuhmann, T Shalaby, M Grotzer… - Cell, 2016 - cell.com
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …

[PDF][PDF] Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

…, S Stark, J Meyer, T Milde, M Schuhmann, M Ebinger… - Cancer cell, 2013 - cell.com
Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified
in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups …

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

…, T Milde, AE Kulozik, M Ebinger, MU Schuhmann… - Nature …, 2013 - nature.com
Pilocytic astrocytoma, the most common childhood brain tumor 1 , is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations 2 . Surgically inaccessible …

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

…, R Volckmann, J Koster, MU Schuhmann, M Ebinger… - Nature, 2014 - nature.com
Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to …