User profiles for M. Mulè

Matthew P. Mulè

University of Cambridge | NIH OxCam | UNC Chapel Hill MSTP
Verified email at cam.ac.uk
Cited by 879

Circulating biomarkers in pulmonary arterial hypertension: update and future direction

…, R Poscia, S Ghio, M D'Alto, P Vitulo, M Mulè… - The Journal of Heart and …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is a complex disease with a poor prognosis. In
recent years, great advances have occurred in our understanding of the pathophysiologic …

Dual antiplatelet therapy versus aspirin alone in patients undergoing transcatheter aortic valve implantation

GP Ussia, M Scarabelli, M Mulè, M Barbanti… - The American journal of …, 2011 - Elsevier
Dual antiplatelet therapy (DAPT) with clopidogrel and aspirin is a widely accepted strategy
in patients undergoing transcatheter aortic valve implantation (TAVI), but this approach is not …

[HTML][HTML] Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination

S Fourati, LE Tomalin, MP Mulè, DG Chawla… - Nature …, 2022 - nature.com
Several studies have shown that the pre-vaccination immune state is associated with the
antibody response to vaccination. However, the generalizability and mechanisms that underlie …

Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells

…, GV Reynoso, VL Coble, GM Lynn, MP Mule… - Nature …, 2021 - nature.com
Personalized cancer vaccines are a promising approach for inducing T cell immunity to tumor
neoantigens. Using a self-assembling nanoparticle vaccine that links neoantigen peptides …

New perspectives on management of idiopathic pulmonary fibrosis

…, R Giuliano, S Palmucci, M Mulè… - … in Chronic Disease, 2016 - journals.sagepub.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive parenchymal lung disease
characterized by a median survival of 3–5 years following diagnosis. The diagnosis is based on …

Exercise stress echocardiography of the pulmonary circulation: limits of normal and sex differences

…, RR Vanderpool, M Mulè, MG Russo, M D'Alto… - Chest, 2012 - Elsevier
… /min/m 2 for men and 2.8 L/min/m 2 for women.24, 25 However, in these studies, body
size-corrected right ventricular volume and mass were lower in women.24, 25 The present results …

Exercise stress echocardiography for the study of the pulmonary circulation

P Argiento, N Chesler, M Mulè, M D'Alto… - European …, 2010 - Eur Respiratory Soc
Exercise stress tests have been used for the diagnosis of pulmonary hypertension, but with
variable protocols and uncertain limits of normal. The pulmonary haemodynamic response to …

[HTML][HTML] Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

…, B Gerritsen, LE Tomalin, S Fourati, MP Mulè… - Nature …, 2022 - nature.com
Abstract Systems vaccinology has defined molecular signatures and mechanisms of immunity
to vaccination. However, comparative analysis of immunity to different vaccines is lacking. …

Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus

…, R Sparks, AJ Martins, MP Mulè, Y Lu, M Goswami… - Nature medicine, 2020 - nature.com
Responses to vaccination and to diseases vary widely across individuals, which may be
partly due to baseline immune variations. Identifying such baseline predictors of immune …

[HTML][HTML] Normalizing and denoising protein expression data from droplet-based single cell profiling

MP Mulè, AJ Martins, JS Tsang - Nature communications, 2022 - nature.com
Multimodal single-cell profiling methods that measure protein expression with oligo-conjugated
antibodies hold promise for comprehensive dissection of cellular heterogeneity, yet the …