Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

…, M Martinez-Losa, TR Walker, R Duffin, M Gray… - Nature medicine, 2006 - nature.com
Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent
efficient resolution of inflammation. Here we report that human neutrophils contain …

[PDF][PDF] Nav1. 1-overexpressing interneuron transplants restore brain rhythms and cognition in a mouse model of Alzheimer's disease

M Martinez-Losa, TE Tracy, K Ma, L Verret… - Neuron, 2018 - cell.com
Martinez-Losa et al. show that the level of the voltage-gated sodium channel subunit
Nav1.1 in interneuron transplants regulates their therapeutic efficacy in an AD mouse model. …

Hypoxia promotes efficient differentiation of human embryonic stem cells to functional endothelium

…, A Conesa, A Armińán, M Martínez-Losa… - Stem Cells, 2010 - academic.oup.com
Early development of mammalian embryos occurs in an environment of relative hypoxia.
Nevertheless, human embryonic stem cells (hESC), which are derived from the inner cell mass …

[HTML][HTML] In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats

…, N Prats, S Blesa, M Martinez-Losa… - British journal of …, 2003 - ncbi.nlm.nih.gov
… The pooled BALF was filtered through sterile gauze and then centrifuged at 300 × g for 10
min, the erythrocytes were lysed, and after washing three times in RPMI-1640 media, the …

Specific contribution of Reelin expressed by Cajal–Retzius cells or GABAergic interneurons to cortical lamination

…, M Martínez-Losa, M Pascual… - Proceedings of the …, 2022 - National Acad Sciences
The extracellular protein Reelin, expressed by Cajal–Retzius (CR) cells at early stages of
cortical development and at late stages by GABAergic interneurons, regulates radial migration …

Oral N‐acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats

…, A Ruiz, M Cerda, M Martinez-Losa… - European …, 2003 - Eur Respiratory Soc
Oxidative stress is involved in the pathogenesis of pulmonary fibrosis, therefore antioxidants
may be of therapeutic value. Clinical work indicates that N‐acetylcysteine (NAC) may be …

Bronchodilator and anti‐inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes

…, M Martí‐Cabrera, M MartinezLosa… - British journal of …, 1999 - Wiley Online Library
Selective phosphodiesterase 4 (PDE4) inhibitors are of potential interest in the treatment of
asthma. We examined the effects of the alkaloid S‐(+)‐glaucine, a PDE4 inhibitor, on human …

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult …

…, M Martínez-Losa, M Álvarez-Dolado… - Disease models & …, 2017 - journals.biologists.com
Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional
pathology that impedes recovery. We studied whether a persistent cognitive/emotional …

Olive oil–based lipid Emulsion's neutral effects on neutrophil functions and leukocyte–endothelial cell interactions

…, M MartinezLosa, M Mata… - Journal of Parenteral …, 2006 - Wiley Online Library
Background: Infection remains a drawback of parenteral nutrition (PN), probably related,
among other factors, to immunosuppressive effects of its lipid component. Newer preparations …

Cell fusion and tissue regeneration

M Álvarez-Dolado, M Martínez-Losa - Cell Fusion in Health and Disease, 2011 - Springer
Cell fusion is a natural process implicated in normal development, immune response, tissue
formation, and with a prominent role in stem cell plasticity. The discovery that bone marrow …