… 10 and 2.5 μ m in diameter are classified as coarse (PM 10 ), particles between 2.5 μ m and
0.1 μ m in diameter are classified as fine, and particles with a diameter less than 0.1 μ m are …

In human blood two monocyte populations can be distinguished, ie, the CD14++ CD16− DR+
classical monocytes and the CD14+ CD16+ DR++ proinflammatory monocytes that …

Blood of both humans and mice contains 2 main monocyte subsets. Here, we investigated the
extent of their similarity using a microarray approach. Approximately 270 genes in humans …

Background Pirfenidone has been shown to slow disease progression in patients with
idiopathic pulmonary fibrosis (IPF). However, there are few treatment options for progressive …

The subset of human blood monocytes expressing low levels of CD14 and high levels of
CD16 (CD14 + CD16 + ) exhibits features resembling mature tissue macrophages and can be …

The subpopulation of strongly CD14-positive (CD14++) monocytes and monocytes
coexpressing the CD16 antigen and low levels of CD14 (CD14+/CD16+ cells) were isolated by …

Objective There is a paucity of observational data on antifibrotic therapy for idiopathic pulmonary
fibrosis (IPF). We aimed to assess the course of disease of IPF patients with and without …

Background The INSIGHTS-IPF registry provides one of the largest data sets of clinical data
and self-reported patient related outcomes including health related quality of life (QoL) on …

… Marion Frankenberger was involved in the study design and performed experiments. Jürgen
Scherberich provided clinical samples. Loems Ziegler-Heitbrock was involved in the study …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by lung
epithelial cell injury, increased (myo)fibroblast activation, and extracellular matrix deposition. …