The existence of a continuous array of sympatric biotypes—from polymorphisms, through
ecological or host races with increasing reproductive isolation, to good species—can provide …

Assessing respiratory mechanics and muscle function is critical for both clinical practice and
research purposes. Several methodological developments over the past two decades have …

Diaphragm weakness is highly prevalent in critically ill patients. It may exist prior to ICU
admission and may precipitate the need for mechanical ventilation but it also frequently develops …

Background Patients with COVID-19 who develop severe acute respiratory distress syndrome
(ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and death. The …

Rationale: Diaphragm dysfunction worsens outcomes in mechanically ventilated patients,
but the clinical impact of potentially preventable changes in diaphragm structure and function …

Background In the Île-de-France region (henceforth termed Greater Paris), extracorporeal
membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was …

Methods All consecutive patients with acute respiratory failure and laboratory-confirmed
SARS-CoV-2 infection admitted to one of the four participating dedicated COVID-19 ICUs in …

Rationale: Intensive care unit (ICU)- and mechanical ventilation (MV)-acquired limb muscle
and diaphragm dysfunction may both be associated with longer length of stay and worse …

Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is
associated with poor clinical outcomes. Although the importance and impact of lung-protective …

Early management of respiratory muscle failure using mechanical ventilation and high-dose
abatacept with CD86 receptor occupancy monitoring combined with ruxolitinib may be …