User profiles for M. Dolovich

Myrna Dolovich

Professor, Medicine, McMaster University
Verified email at mcmaster.ca
Cited by 15557

Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications

NR Labiris, MB Dolovich - British journal of clinical …, 2003 - Wiley Online Library
As the end organ for the treatment of local diseases or as the route of administration for systemic
therapies, the lung is a very attractive target for drug delivery. It provides direct access to …

Device selection and outcomes of aerosol therapy: evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and …

MB Dolovich, RC Ahrens, DR Hess, P Anderson… - Chest, 2005 - Elsevier
Background The proliferation of inhaler devices has resulted in a confusing number of
choices for clinicians who are selecting a delivery device for aerosol therapy. There are …

Aerosol drug delivery: developments in device design and clinical use

MB Dolovich, R Dhand - The Lancet, 2011 - thelancet.com
Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering
drugs by inhalation requires a formulation that can be successfully aerosolised and a …

Significant variability in response to inhaled corticosteroids for persistent asthma

…, VM Chinchilli, TJ Craig, M Dolovich… - Journal of Allergy and …, 2002 - Elsevier
Background: A clinical model is needed to compare inhaled corticosteroids (ICSs) with
respect to efficacy. Objective: The purpose of this investigation was to compare the relative …

Regional distribution of inspired gas in the lung.

…, JA Henderson, MB Dolovich… - Journal of applied …, 1966 - journals.physiology.org
METHODS The experiments were made on nine healthy men sitting upright. Details of
physical characteristics, lung volumes, and vertical lung length at maximal inspiration

Regional distribution of ventilation and perfusion as a function of body position.

K Kaneko, J Milic-Emili, MB Dolovich… - Journal of Applied …, 1966 - journals.physiology.org
KANEKO, K., J. MILIC-EMCLI, MB DOLOVICH, A. DAW-SON, AND DV BATES. Regional
distribution of ventilation and perjusion as a function of body position. J. Appl. Physiol. 2 I (3): …

Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications

NR Labiris, MB Dolovich - British journal of clinical …, 2003 - Wiley Online Library
Research in the area of pulmonary drug delivery has gathered momentum in the last several
years, with increased interest in using the lung as a means of delivering drugs systemically. …

Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia

DS Southam, M Dolovich… - American Journal of …, 2002 - journals.physiology.org
Intranasal instillation techniques are used to deliver various substances to the upper and
lower respiratory tract (URT and LRT) in mice. Here, we quantify the relative distribution …

Systemic effect comparisons of six inhaled corticosteroid preparations

…, VM Chinchilli, M Kraft, M Dolovich… - American journal of …, 2002 - atsjournals.org
The goal of this study was to establish a reliable method to evaluate systemic bioavailability
and to determine equisystemic effects (microgram dose producing equal systemic cortisol …

Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia

TF Fok, S Monkman, M Dolovich, S Gray… - Pediatric …, 1996 - Wiley Online Library
… by perfusion scanning (M. Dolovich, personal communication). The airways and the
lungs were delineated as the areas of interest on the computer screen, and the amount of …