Mice have proved to be powerful models for understanding obesity in humans and farm
animals. Single-gene mutants and genetically modified mice have been used successfully to …

The two main phenotypes of inflammatory bowel disease (IBD)—Crohn's disease (CD) and
ulcerative colitis (UC)—are chronic intestinal inflammatory disorders with a complex genetic …

Celiac disease is probably the best-understood immune-related disorder. The disease presents
in the small intestine and results from the interplay between multiple genes and gluten, …

Recently, association of celiac disease with common single-nucleotide polymorphism (SNP)
variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, …

Inherited white-matter disorders are a broad class of diseases for which treatment and
classification are both challenging. Indeed, nearly half of the children presenting with a …

Background: Coeliac disease (gluten-sensitive enteropathy; GSE) and inflammatory bowel
disease (IBD) are common gastrointestinal disorders. Both display enhanced intestinal …

The Krebs cycle is of fundamental importance for the generation of the energetic and
molecular needs of both prokaryotic and eukaryotic cells. Both enantiomers of metabolite 2-…

Haplotypes are fundamental to fully characterize the diploid genome of an individual, yet
methods to directly chart the unique genetic makeup of each parental chromosome are lacking. …

In December 2019, the first cases of pneumonia of unknown etiology were found in Wuhan (China).
Later, the pneumonia was associated with a new coronavirus; in February 2020, the …

Hereditary ataxias are clinically and genetically heterogeneous neurodegenerative
disorders. Although many ataxia genes have been identified, about 50% of cases await the …