User profiles for M. A. Birrell
Mark BirrellVerified email at astrazeneca.com Cited by 9150 |
Transient receptor potential (TRP) channels in the airway: role in airway disease
Over the last few decades, there has been an explosion of scientific publications reporting
the many and varied roles of transient receptor potential ( TRP ) ion channels in physiological …
the many and varied roles of transient receptor potential ( TRP ) ion channels in physiological …
Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation
MG Belvisi, DJ Hele, MA Birrell - European journal of pharmacology, 2006 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription
factor belonging to the nuclear hormone receptor superfamily. PPARγ regulates several …
factor belonging to the nuclear hormone receptor superfamily. PPARγ regulates several …
Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance
CS Stevenson, MA Birrell - Pharmacology & therapeutics, 2011 - Elsevier
… Birrell's salary as well as Drs. Stevenson and Birrell's work developing models of cigarette
smoke-induced lung inflammation and lung damage at Imperial College is supported by a …
smoke-induced lung inflammation and lung damage at Imperial College is supported by a …
Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with …
…, C Sacerdote, F Ricceri, MA Birrell… - Human molecular …, 2013 - academic.oup.com
A single cytosine–guanine dinucleotide (CpG) site within coagulation factor II (thrombin)
receptor-like 3 (F2RL3) was recently found to be hypomethylated in peripheral blood genomic …
receptor-like 3 (F2RL3) was recently found to be hypomethylated in peripheral blood genomic …
[HTML][HTML] Lung-resident eosinophils represent a distinct regulatory eosinophil subset
…, G Paulissen, X Xiao, MA Birrell… - The Journal of …, 2016 - Am Soc Clin Investig
Increases in eosinophil numbers are associated with infection and allergic diseases, including
asthma, but there is also evidence that eosinophils contribute to homeostatic immune …
asthma, but there is also evidence that eosinophils contribute to homeostatic immune …
[HTML][HTML] Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti …
Background At present, nothing is known of the role of miRNAs in the immune response in
vivo despite the fact that inflammation is thought to underlie multiple acute and chronic …
vivo despite the fact that inflammation is thought to underlie multiple acute and chronic …
TRPA1 agonists evoke coughing in guinea pig and human volunteers
Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a
general or respiratory physician. Treatment options are limited and one meta-analysis …
general or respiratory physician. Treatment options are limited and one meta-analysis …
Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF‐κB‐independent mechanism
MA Birrell, K McCluskie, S Wong… - The FASEB …, 2005 - Wiley Online Library
Consumption of a naturally occurring polyphenol, resveratrol, in particular through drinking
moderate amounts of red wine, has been suggested to be beneficial to health. A plethora of …
moderate amounts of red wine, has been suggested to be beneficial to health. A plethora of …
Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin
Background Cough is the most frequent reason for consultation with a family doctor, or with
a general or respiratory physician. Treatment options are limited and a recent meta-analysis …
a general or respiratory physician. Treatment options are limited and a recent meta-analysis …
Theobromine inhibits sensory nerve activation and cough
…, MG Belvisi, HJ Patel, N Crispino, MA Birrell… - The FASEB …, 2005 - Wiley Online Library
Cough is a common and protective reflex, but persistent coughing is debilitating and impairs
quality of life. Antitussive treatment using opioids is limited by unacceptable side effects, …
quality of life. Antitussive treatment using opioids is limited by unacceptable side effects, …