User profiles for Lucy Fairclough

Professor Lucy Fairclough

Professor of Immunology, The University of Nottingham
Verified email at nottingham.ac.uk
Cited by 3035

ELISA in the multiplex era: potentials and pitfalls

…, RR Ryder, I Todd, LC Fairclough - PROTEOMICS–Clinical …, 2015 - Wiley Online Library
Multiplex immunoassays confer several advantages over widely adopted singleplex
immunoassays including increased efficiency at a reduced expense, greater output per sample …

Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

N Lane, RA Robins, J Corne, L Fairclough - Clinical science, 2010 - portlandpress.com
COPD (chronic obstructive pulmonary disease) is an inflammatory disorder of the airways,
which is associated with irreversible airway obstruction. The pathological hallmarks of COPD …

Quantitative validation and comparison of multiplex cytokine kits

…, J Corne, P O'Shea, L Fairclough - Journal of …, 2010 - journals.sagepub.com
The focus of biomarker studies is shifting toward deciphering patterns of biomolecules as
they provide a more comprehensive depiction of disease than individual biomarkers. …

[HTML][HTML] Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients

…, JR Lamb, I Todd, JM Corne, LC Fairclough - Respiratory …, 2010 - Springer
Background We have previously shown that NK (CD56 + CD3 - ) and NKT-like (CD56 + CD3
+ ) cells are reduced in both numbers and cytotoxicity in peripheral blood. The aim of the …

Utility, reliability and reproducibility of immunoassay multiplex kits

P Tighe, O Negm, I Todd, L Fairclough - Methods, 2013 - Elsevier
Multiplex technologies are becoming increasingly important in biomarker studies as they
enable patterns of biomolecules to be examined, which provide a more comprehensive …

Prophylactic antibiotic use in COPD and the potential anti-inflammatory activities of antibiotics

AW Huckle, LC Fairclough, I Todd - Respiratory care, 2018 - rc.rcjournal.com
Antibiotics have previously demonstrated anti-inflammatory properties, and they have been
linked to therapeutic benefit in several pulmonary conditions that feature inflammation. …

Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review

…, I Todd, PJ Tighe, LC Fairclough - Basic & Clinical …, 2019 - Wiley Online Library
The aim of the present study was to compare concentrations of IgG, IgA, IgM and IgD in both
serum and saliva samples from smoking and non‐smoking individuals using a protein …

[HTML][HTML] Highly sensitive label-free antibody detection using a long period fibre grating sensor

…, SP Morgan, SW Lee, P Tighe, L Fairclough… - Sensors and Actuators B …, 2018 - Elsevier
An optical fibre long period grating (LPG) biosensor is appealing in the detection of
biomolecules because of the high sensitivity, label-free and real-time measurement. The …

[HTML][HTML] Altered effector function of peripheral cytotoxic cells in COPD

…, JR Lamb, I Todd, JM Corne, LC Fairclough - Respiratory …, 2009 - Springer
Background There is mounting evidence that perforin and granzymes are important mediators
in the lung destruction seen in COPD. We investigated the characteristics of the three …

[HTML][HTML] The role of CD8+ T lymphocytes in chronic obstructive pulmonary disease: a systematic review

M Williams, I Todd, LC Fairclough - Inflammation Research, 2021 - Springer
Objective and design This systematic review aims to establish the role of CD8 + T lymphocytes
in COPD. Methods Forty-eight papers published in the last 15 years were identified for …