[HTML][HTML] Clustering drug-drug interaction networks with energy model layouts: community analysis and drug repurposing

L Udrescu, L Sbārcea, A Topīrceanu, A Iovanovici… - Scientific reports, 2016 - nature.com
Analyzing drug-drug interactions may unravel previously unknown drug action patterns,
leading to the development of new drug discovery tools. We present a new approach to …

Betulonic acid—cyclodextrins inclusion complexes

L Sbārcea, A Ledeţi, L Udrescu, RM Văruţ… - Journal of Thermal …, 2019 - Springer
Betulonic acid (BA) is a pentacyclic lupane-type triterpenoid possessing valuable
pharmacological activities, exhibiting very low water solubility. Inclusion complexes between the …

Fractional dynamics foster deep learning of COPD stage prediction

C Yin, M Udrescu, G Gupta, M Cheng, A Lihu… - Advanced …, 2023 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide.
Current COPD diagnosis (ie, spirometry) could be unreliable because the test depends …

[HTML][HTML] Drug repurposing using modularity clustering in drug-drug similarity networks based on drug–gene interactions

V Groza, M Udrescu, A Bozdog, L Udrescu - Pharmaceutics, 2021 - mdpi.com
Drug repurposing is a valuable alternative to traditional drug design based on the
assumption that medicines have multiple functions. Computer-based techniques use ever-growing …

[HTML][HTML] Analyzing neck circumference as an indicator of CPAP treatment response in obstructive sleep apnea with network medicine

S Mihaicuta, L Udrescu, M Udrescu, IA Toth… - Diagnostics, 2021 - mdpi.com
We explored the relationship between obstructive sleep apnea (OSA) patients’ anthropometric
measures and the CPAP treatment response. To that end, we processed three non-…

A drug repurposing method based on drug-drug interaction networks and using energy model layouts

M Udrescu, L Udrescu - Computational Methods for Drug Repurposing, 2019 - Springer
Complex network representations of reported drug-drug interactions foster computational
strategies that can infer pharmacological functions which, in turn, create incentives for drug …

[HTML][HTML] Uncovering new drug properties in target-based drug–drug similarity networks

L Udrescu, P Bogdan, A Chiş, IO Sīrbu, A Topīrceanu… - Pharmaceutics, 2020 - mdpi.com
Despite recent advances in bioinformatics, systems biology, and machine learning, the accurate
prediction of drug properties remains an open problem. Indeed, because the biological …

[HTML][HTML] Gender phenotyping of patients with obstructive sleep apnea syndrome using a network science approach

A Topīrceanu, L Udrescu, M Udrescu… - Journal of Clinical …, 2020 - mdpi.com
We defined gender-specific phenotypes for men and women diagnosed with obstructive sleep
apnea syndrome (OSAS) based on easy-to-measure anthropometric parameters, using a …

[HTML][HTML] Network science meets respiratory medicine for OSAS phenotyping and severity prediction

S Mihaicuta, M Udrescu, A Topirceanu, L Udrescu - PeerJ, 2017 - peerj.com
Obstructive sleep apnea syndrome (OSAS) is a common clinical condition. The way that
OSAS risk factors associate and converge is not a random process. As such, defining OSAS …

[HTML][HTML] SAS score: Targeting high-specificity for efficient population-wide monitoring of obstructive sleep apnea

A Topīrceanu, M Udrescu, L Udrescu, C Ardelean… - PloS one, 2018 - journals.plos.org
Proposal This paper investigates a novel screening tool for Obstructive Sleep Apnea Syndrome
(OSAS), which aims at efficient population-wide monitoring. To this end, we introduce …