[HTML][HTML] Clustering drug-drug interaction networks with energy model layouts: community analysis and drug repurposing
Analyzing drug-drug interactions may unravel previously unknown drug action patterns,
leading to the development of new drug discovery tools. We present a new approach to …
leading to the development of new drug discovery tools. We present a new approach to …
Betulonic acid—cyclodextrins inclusion complexes
Betulonic acid (BA) is a pentacyclic lupane-type triterpenoid possessing valuable
pharmacological activities, exhibiting very low water solubility. Inclusion complexes between the …
pharmacological activities, exhibiting very low water solubility. Inclusion complexes between the …
Fractional dynamics foster deep learning of COPD stage prediction
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide.
Current COPD diagnosis (ie, spirometry) could be unreliable because the test depends …
Current COPD diagnosis (ie, spirometry) could be unreliable because the test depends …
[HTML][HTML] Drug repurposing using modularity clustering in drug-drug similarity networks based on drug–gene interactions
Drug repurposing is a valuable alternative to traditional drug design based on the
assumption that medicines have multiple functions. Computer-based techniques use ever-growing …
assumption that medicines have multiple functions. Computer-based techniques use ever-growing …
[HTML][HTML] Analyzing neck circumference as an indicator of CPAP treatment response in obstructive sleep apnea with network medicine
S Mihaicuta, L Udrescu, M Udrescu, IA Toth… - Diagnostics, 2021 - mdpi.com
We explored the relationship between obstructive sleep apnea (OSA) patients’ anthropometric
measures and the CPAP treatment response. To that end, we processed three non-…
measures and the CPAP treatment response. To that end, we processed three non-…
A drug repurposing method based on drug-drug interaction networks and using energy model layouts
M Udrescu, L Udrescu - Computational Methods for Drug Repurposing, 2019 - Springer
Complex network representations of reported drug-drug interactions foster computational
strategies that can infer pharmacological functions which, in turn, create incentives for drug …
strategies that can infer pharmacological functions which, in turn, create incentives for drug …
[HTML][HTML] Uncovering new drug properties in target-based drug–drug similarity networks
Despite recent advances in bioinformatics, systems biology, and machine learning, the accurate
prediction of drug properties remains an open problem. Indeed, because the biological …
prediction of drug properties remains an open problem. Indeed, because the biological …
[HTML][HTML] Gender phenotyping of patients with obstructive sleep apnea syndrome using a network science approach
A Topīrceanu, L Udrescu, M Udrescu… - Journal of Clinical …, 2020 - mdpi.com
We defined gender-specific phenotypes for men and women diagnosed with obstructive sleep
apnea syndrome (OSAS) based on easy-to-measure anthropometric parameters, using a …
apnea syndrome (OSAS) based on easy-to-measure anthropometric parameters, using a …
[HTML][HTML] Network science meets respiratory medicine for OSAS phenotyping and severity prediction
Obstructive sleep apnea syndrome (OSAS) is a common clinical condition. The way that
OSAS risk factors associate and converge is not a random process. As such, defining OSAS …
OSAS risk factors associate and converge is not a random process. As such, defining OSAS …
[HTML][HTML] SAS score: Targeting high-specificity for efficient population-wide monitoring of obstructive sleep apnea
A Topīrceanu, M Udrescu, L Udrescu, C Ardelean… - PloS one, 2018 - journals.plos.org
Proposal This paper investigates a novel screening tool for Obstructive Sleep Apnea Syndrome
(OSAS), which aims at efficient population-wide monitoring. To this end, we introduce …
(OSAS), which aims at efficient population-wide monitoring. To this end, we introduce …