Variants in pharmacokinetic transporters and glycemic response to metformin: a Metgen meta‐analysis

T Dujic, K Zhou, SW Yee… - Clinical …, 2017 - Wiley Online Library
Therapeutic response to metformin, a first‐line drug for type 2 diabetes (T2D), is highly
variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have …

KCNJ11 gene E23K variant and therapeutic response to sulfonylureas

M Javorsky, L Klimcakova, Z Schroner, J Zidzik… - European journal of …, 2012 - Elsevier
AIMS: Potassium inwardly rectifier 6.2 subunit (Kir6.2) of the ATP-sensitive potassium (K
ATP ) channel encoded by KCNJ11 gene is a therapeutical target for sulfonylureas. KCNJ11 …

The subcellular localization of vaccinia‐related kinase‐2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

S Blanco, L Klimcakova, FM Vega, PA Lazo - The FEBS journal, 2006 - Wiley Online Library
VRK is a new kinase family of unknown function. Endogenous human vacinia‐related kinase
2 (VRK2) protein is present in both the nucleus and the cytosol, which is a consequence of …

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to …

L Zaharenko, I Kalnina, K Geldnere… - European Journal of …, 2016 - academic.oup.com
Objective(s) High variability in clinical response to metformin is often observed in type 2
diabetes (T2D) patients, and it highlights the need for identification of genetic components …

Genetic variants associated with glycemic response to treatment with dipeptidylpeptidase 4 inhibitors

A Űrgeová, M Javorský, L Klimčáková, J Židzik… - …, 2020 - Future Medicine
Aim: We examined associations of eight SNPs in/near seven candidate genes with glycemic
response to 6 month treatment with DPP4 inhibitors. Patients & methods: 206 patients with …

KCNQ1 gene polymorphism is associated with glycaemic response to treatment with DPP-4 inhibitors

I Gotthardová, M Javorský, L Klimčáková… - diabetes research and …, 2017 - Elsevier
Aims Only a few gene variants were associated with the response to dipeptidylpeptidase-4
inhibitors (DPP4I). KCNQ1 gene variants were previously related both to type 2 diabetes (T2D…

[HTML][HTML] Variation in KCNQ1 is associated with therapeutic response to sulphonylureas

Z Schroner, M Dobrikova, L Klimcakova… - … medical journal of …, 2011 - ncbi.nlm.nih.gov
… Zbynek Schroner, 1, B, D, E Martina Dobrikova, 1, B, C, F Lucia Klimcakova, 2, B, E
Martin Javorsky, 1, C, D, E Jozef Zidzik, 2, B Miriam Kozarova, 2, B Terezia Hudakova, 2, B …

[HTML][HTML] Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide

M Javorský, E Babjaková, L Klimčáková… - International Journal of …, 2013 - hindawi.com
Previous studies showed associations between variants in TCF7L2 gene and the therapeutic
response to sulfonylureas. All sulfonylureas stimulate insulin secretion by the closure of …

A pharmacogenetic association between a variation in calpain 10 (CAPN10) gene and the response to metformin treatment in patients with type 2 diabetes

I Tkáč, M Javorský, L Klimčáková, J Židzik… - European journal of …, 2015 - Springer
Purpose The aim of the present study was to investigate possible associations of the single-nucleotide
variants in six genes encoding the key molecules mediating the metformin …

[HTML][HTML] MDR1 polymorphisms and idiopathic nephrotic syndrome in Slovak children: preliminary results

M Cizmarikova, L Podracka, L Klimcakova… - … Medical Journal of …, 2015 - ncbi.nlm.nih.gov
Background The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms
1236T> C, 2677T> G, and 3435T> C was studied in relation to susceptibility, demographics, …