The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …

Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate
asthma into a T2-high phenotype. We examined whether currently available clinical …

Background Adult-onset severe asthma is characterized by highly symptomatic disease
despite high-intensity asthma treatments. Understanding of the underlying pathways of this …

International guidelines recommend that severe asthma can only be diagnosed after
contributory factors, including adherence, have been addressed. Accurate assessment of …

Severe asthma patients with a significant smoking history have airflow obstruction with
reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of …

To the Editor: Acute wheeze in preschool children accounts for more than 75% of pediatric
health care attendances for wheeze/asthma in the United Kingdom. 1 The high morbidity …

Background Allergic sensitization is associated with severe asthma, but assessment of
sensitization is not recommended by most guidelines. Objective We hypothesized that patterns of …

Background Transcriptomic changes in patients who respond clinically to biological therapies
may identify responses in other tissues or diseases. Objective We sought to determine …