Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery

E Kilger, F Weis, J Briegel, L Frey, AE Goetz… - Critical care …, 2003 - journals.lww.com
Objective Severe systemic inflammation with a vasodilatory syndrome occurs in about one
third of all patients after cardiac surgery with cardiopulmonary bypass. Hydrocortisone has …

Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression

J Groetzner, F Kur, F Spelsberg, J Behr, L Frey… - The Journal of heart and …, 2004 - Elsevier
A prospective, pilot trial was started to evaluate the effect of a sirolimus-based immunosuppressive
regimen on acute and chronic rejection in de novo lung transplant patients. Primary …

[HTML][HTML] Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study

…, LM Holdt, M Bruegel, T Weig, B Grabein, L Frey… - Critical Care, 2014 - Springer
Introduction Severe infections in intensive care patients show high morbidity and mortality
rates. Linezolid is an antimicrobial drug frequently used in critically ill patients. Recent data …

Limiting life-sustaining treatment in German intensive care units: a multiprofessional survey

RJ Jox, M Krebs, M Fegg, S Reiter-Theil, L Frey… - Journal of critical …, 2010 - Elsevier
PURPOSE: Deciding about the limitation of life-sustaining treatment (LST) is a major challenge
for intensive care medicine. The aim of the study was to investigate the practices and …

Quantification of piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in serum using an isotope dilution UHPLC-MS/MS method with semi …

J Zander, B Maier, A Suhr, M Zoller, L Frey… - Clinical Chemistry and …, 2015 - degruyter.com
Background: Recent studies have demonstrated highly variable blood concentrations of
piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in critically ill …

[HTML][HTML] Blood pressure measurement using only a smartphone

L Frey, C Menon, M Elgendi - NPJ digital medicine, 2022 - nature.com
Hypertension is an immense challenge in public health. As one of the most prevalent medical
conditions worldwide, it is a major cause of premature death. At present, the detection, …

[HTML][HTML] Piperacillin concentration in relation to therapeutic range in critically ill patients–a prospective observational study

…, B Maier, C Scharf, M Huseyn-Zada, J Jung, L Frey… - Critical Care, 2016 - Springer
Background Piperacillin levels after standard dosing have been shown frequently to be
subtherapeutic, especially when renal clearance was augmented. Here, we aimed to determine …

Core muscle size predicts postoperative outcome in lung transplant candidates

…, R Schramm, H Winter, C Neurohr, L Frey… - The Annals of thoracic …, 2016 - Elsevier
Background Careful patient selection is the prerequisite to raise transplant benefit. In lung
transplant (LT) candidates, the effect of body mass index (BMI) on postoperative outcome …

[HTML][HTML] Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational …

…, N Hartung, W Huisinga, M Vogeser, L Frey… - Critical care, 2017 - Springer
Background Severe bacterial infections remain a major challenge in intensive care units
because of their high prevalence and mortality. Adequate antibiotic exposure has been …

Potential functional and survival benefit of double over single lung transplantation for selected patients with idiopathic pulmonary fibrosis

…, R Hatz, S Czerner, L Frey… - Transplant …, 2010 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a frequent indication for lung transplantation (LTX) with
pulmonary hypertension (PH) negatively affecting outcome. The optimal procedure type …