Antibiotic-resistant bacteria threaten life worldwide. Although new antibiotics are scarce, the
use of bacteriophages, viruses that infect bacteria, is rarely proposed as a means of …

Multidrug-resistant bacteria are the cause of an increasing number of deadly pulmonary
infections. Because there is currently a paucity of novel antibiotics, phage therapy—the use of …

Background The human lung is exposed to a large number of airborne pathogens as a result
of the daily inhalation of 10,000 liters of air. Innate immunity is thus essential to defend the …

Genetically modified mice have been studied for more than fifteen years as models of cystic
fibrosis (CF). The large amount of experimental data generated illuminates the complex multi…

Lyso-phospholipids exert a major injurious effect on lung cell membranes during Acute
Respiratory Distress Syndrome (ARDS), but the mechanisms leading to their in vivo generation …

Young cystic fibrosis (CF) patients’ airways are mainly colonized by Staphylococcus aureus,
while Pseudomonas aeruginosa predominates in adults. However, the mechanisms behind …

Phospholipases A2 (PLA2s) represent a growing family of enzymes that catalyze the
hydrolysis of phospholipids at the sn-2 position leading to the generation of free fatty acids and …

Background Methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas
aeruginosa are becoming difficult to treat with antibiotics whereas Cationic Antimicrobial …

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that is characterized
by arterial hypoxemia and noncardiogenic pulmonary oedema. One feature of ARDS is …

Previous studies have established that phagocytes are key cells of the pulmonary innate
immune defense against A. fumigatus, an opportunistic fungus responsible of invasive …