Randomised controlled trial of nasal continuous positive airways pressure (CPAP) in bronchiolitis

LP Thia, SA McKenzie, TP Blyth… - Archives of Disease in …, 2008 - adc.bmj.com
Aims: To compare continuous positive airways pressure (CPAP) with standard treatment (ST)
in the management of bronchiolitis. Methods: Children <1 year of age with bronchiolitis and …

Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening

AF Hoo, LP Thia, A Bush, J Chudleigh, S Lum… - Thorax, 2012 - thorax.bmj.com
Background Long-term benefits of newborn screening (NBS) for cystic fibrosis (CF) have
been established with respect to nutritional status, but effects on pulmonary health remain …

Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants

LP Thia, AF Hoo, A Bush, P Aurora, A Wade… - Thorax, 2014 - thorax.bmj.com
Rationale Newborn screening (NBS) for cystic fibrosis (CF) allows early intervention.
Design of randomised controlled trials (RCT) is currently impeded by uncertainty regarding …

[HTML][HTML] The CF-Sputum Induction Trial (CF-SpIT) to assess lower airway bacterial sampling in young children with cystic fibrosis: a prospective internally controlled …

K Ronchetti, JD Tame, C Paisey, LP Thia… - The Lancet …, 2018 - thelancet.com
Background Pathogen surveillance is challenging but crucial in children with cystic fibrosis—who
are often non-productive of sputum even if actively coughing—because infection and …

Diagnosing allergic bronchopulmonary aspergillosis in children with cystic fibrosis

LP Thia, IMB Lynn - Paediatric respiratory reviews, 2009 - Elsevier
Allergic bronchopulmonary aspergillosis (ABPA) is an important complication of cystic fibrosis.
It is a hypersensitivity reaction to Aspergillus fumigatus, leading to a Th2 CD4 response …

New reference equations to improve interpretation of infant lung function

…, AF Hoo, S Lum, A Wade, LP Thia… - Pediatric …, 2013 - Wiley Online Library
Rationale With increasing use of infant pulmonary function tests (IPFTs) in both clinical and
research studies, appropriate interpretation of results is essential. Objectives To investigate …

Is chest CT useful in newborn screened infants with cystic fibrosis at 1 year of age?

LP Thia, A Calder, J Stocks, A Bush, CM Owens… - Thorax, 2014 - thorax.bmj.com
Rationale Sensitive outcome measures applicable in different centres to quantify and track
early pulmonary abnormalities in infants with cystic fibrosis (CF) are needed both for clinical …

Evaluation and use of childhood lung function tests in cystic fibrosis

J Stocks, LP Thia, S Sonnappa - Current opinion in pulmonary …, 2012 - journals.lww.com
Although limited evidence exists as to whether incorporating lung function tests into routine
clinical care can improve patient outcomes during the early years, this is likely to be helpful in …

Pulmonary function deficits in newborn screened infants with cystic fibrosis managed with standard UK care are mild and transient

G Davies, J Stocks, LP Thia, AF Hoo… - European …, 2017 - Eur Respiratory Soc
With the advent of novel designer molecules for cystic fibrosis (CF) treatment, there is huge
need for early-life clinical trial outcomes, such as infant lung function (ILF). We investigated …

[HTML][HTML] Minimal change in structural, functional and inflammatory markers of lung disease in newborn screened infants with cystic fibrosis at one year

G Davies, LP Thia, J Stocks, A Bush, AF Hoo… - Journal of Cystic …, 2020 - Elsevier
Background With the widespread introduction of newborn screening for cystic fibrosis (CF),
there has been considerable emphasis on the need to develop objective markers of lung …