Pilot studies for phase III trials - which are comparative randomized trials designed to
provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely …

The Consolidated Standards of Reporting Trials (CONSORT) statement is a guideline designed
to improve the transparency and quality of the reporting of randomised controlled trials (…

Context Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung
injury and acute respiratory distress syndrome. Instituting additional strategies to open …

Background Mobile (cell) phone communication has been suggested as a method to improve
delivery of health services. However, data on the effects of mobile health technology on …

We describe a framework for defining pilot and feasibility studies focusing on studies conducted
in preparation for a randomised controlled trial. To develop the framework, we undertook …

Background Recent evidence indicates a potential therapeutic role of fluvoxamine for
COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to …

Background Results from apparently conclusive meta-analyses may be false. A limited
number of events from a few small trials and the associated random error may be under-…

Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

Background: Intraoperative hypotension may contribute to postoperative acute kidney injury
(AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors …

ContextAdherence to antiretroviral therapy is a powerful predictor of survival for individuals
living with human immunodeficiency virus (HIV) and AIDS. Concerns about incomplete …