NF-κB pathway is involved in CRP-induced effects on pulmonary arterial endothelial cells in chronic thromboembolic pulmonary hypertension

M Wynants, L Vengethasamy… - … of Physiology-Lung …, 2013 - journals.physiology.org
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by thrombofibrotic
obstruction of proximal pulmonary arteries. The cellular and molecular mechanisms …

Contribution of circulating angiotensinogen concentrations to variations in aldosterone and blood pressure in a group of African ancestry depends on salt intake

…, OHI Majane, M Badenhorst, L Vengethasamy… - …, 2012 - Am Heart Assoc
In high-Na + , low-K + diets, which suppress renin release in salt-sensitive groups, the
mechanisms maintaining increases in renin-angiotensin-aldosterone system activation …

BMPRII influences the response of pulmonary microvascular endothelial cells to inflammatory mediators

L Vengethasamy, A Hautefort, B Tielemans… - … -European Journal of …, 2016 - Springer
Mutations in the bone morphogenetic protein receptor (BMPR2) gene have been observed
in 70 % of patients with heritable pulmonary arterial hypertension (HPAH) and in 11–40 % …

Dietary-induced obesity hastens the progression from concentric cardiac hypertrophy to pump dysfunction in spontaneously hypertensive rats

OHI Majane, L Vengethasamy, EF du Toit… - …, 2009 - Am Heart Assoc
We explored whether dietary-induced obesity hastens the transition from concentric left
ventricular (LV) hypertrophy to pump dysfunction in spontaneously hypertensive rats (SHRs) and …

Relationship of predominantly mild current smoking to out-of-office blood pressure in a community sample in Africa

…, MJ Maseko, OHI Majane, L Vengethasamy… - Journal of …, 2011 - journals.lww.com
Objectives As the impact of mild smoking on blood pressure (BP) is uncertain, we assessed
the relationship between predominantly mild current smoking and out-of-office BP and the …

Impact of dietary-induced obesity on adrenergic-induced cardiomyocyte damage in rats: obesity and myocardial apoptosis

L Vengethasamy, OHI Majane, GR Norton… - SA Heart, 2009 - journals.co.za
Although obesity is an independent risk factor for heart failure and even mild-to-moderate
forms of obesity are associated with myocardial systolic dysfunction the mechanisms of the …

[PDF][PDF] Impact of obesity on the susceptibility of the myocardium to hypertensive and adrenergic-induced apoptosis

L Vengethasamy - 2009 - wiredspace.wits.ac.za
… I, Leanda Vengethasamy declare that this dissertation is my own work with all assistance
acknowledged. It is being submitted for the degree of Master of Science in Medicine in the …

IL18 induces p38 MAP kinase activation and adhesion capacities in BMPRII knocked down human lung microvascular endothelial cells

L Vengethasamy, R Gijsbers, A Michiels, B Tielemans… - 2016 - Eur Respiratory Soc
Mutations in the bone morphogenetic protein receptor 2 (BMPR2) gene are associated with
heritable pulmonary arterial hypertension (PAH). In addition, BMPRII signalling is impaired …

Il-18 Induces P38 Map Kinase Activation And Adhesion Capacities In Bmpr-Ii Impaired Pulmonary Microvascular Endothelial Cells

L Vengethasamy, R Gijsbers, A Michiels… - … CELLS AND ANIMAL …, 2016 - atsjournals.org
Bone morphogenetic protein receptor II (BMPRII) signaling pathway is impaired in pulmonary
arterial hypertension (PAH) and mutations in the gene have been observed in both …

Inflammatory mediators contribute to pulmonary arterial cell dysfunction in a pulmonary arterial hypertension patient with BMPR2 mutation

L Vengethasamy, R Quarck, M Delcroix - 2013 - Eur Respiratory Soc
Mutations in bone morphogenetic protein receptor (BMPR2) gene have been observed in at
least 70% of patients with heritable pulmonary arterial hypertension (HPAH) and in 11-40% …