This article provides a snapshot of how all 50 states are progressing with the development
and implementation of response-to-intervention (RtI) models 1 year after the final regulations …

Single cell RNA sequencing can yield high-resolution cell-type–specific expression signatures
that reveal new cell types and the developmental trajectories of cell lineages. Here, we …

High-throughput chemical screens typically use coarse assays such as cell survival, limiting
what can be learned about mechanisms of action, off-target effects, and heterogeneous …

The ability to define cell types and how they change during organogenesis is central to our
understanding of animal development and human disease. Despite the crucial nature of this …

Dimensionality reduction is often used to visualize complex expression profiling data. Here,
we use the Uniform Manifold Approximation and Projection (UMAP) method on published …

Here, we present Scribe (https://github.com/aristoteleo/Scribe-py), a toolkit for detecting and
visualizing causal regulatory interactions between genes and explore the potential for single-…

Starch degradation in chloroplasts requires β-amylase (BAM) activity, which is encoded by
a multigene family. Of nine Arabidopsis (Arabidopsis thaliana) BAM genes, six encode …

10.7554/eLife.45181.001 Thyroid hormone (TH) regulates diverse developmental events and
can drive disparate cellular outcomes. In zebrafish, TH has opposite effects on neural crest …

The maturation of single-cell transcriptomic technologies has facilitated the generation of
comprehensive cellular atlases from whole embryos 1 , 2 , 3 – 4 . A majority of these data, …

Mouse models are a critical tool for studying human diseases, particularly developmental
disorders 1 . However, conventional approaches for phenotyping may fail to detect subtle …