The cardiac isoform of the sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA2a) plays a
major role in controlling excitation/contraction coupling. In both experimental and clinical …

Chronic obstructive pulmonary disease (COPD) is a highly prevalent and devastating condition
for which no curative treatment is available. Exaggerated lung cell senescence may be a …

Calcium is a ubiquitous second messenger controlling a broad range of cellular functions
including growth and proliferation. Quiescent, hyperthrophic and proliferating cells have …

The second messengers cAMP and cGMP can be degraded by specific members of the
phosphodiesterase superfamily or by active efflux transporters, namely the multidrug resistance-…

Background: Senescent cells (SCs) are involved in proliferative disorders, but their role in
pulmonary hypertension remains undefined. We investigated SCs in patients with pulmonary …

Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH).
To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (…

Monocytes/macrophages are major effectors of lung inflammation associated with various
forms of pulmonary hypertension (PH). Interactions between the CCL2/CCR2 and CX3CL1/…

Ca 2+ , the main second messenger, is central to the regulation of cellular growth. There is
increasing evidence that cellular growth and proliferation are supported by a continuous store…

The sarco(endo)plasmic reticulum Ca 2+ ATPases (SERCA) system, a key regulator of
calcium cycling and signaling, is composed of several isoforms. We aimed to characterize the …

Adipose tissue macrophages (ATMs) play an important role in obesity and inflammation,
and they accumulate in adipose tissue (AT) with aging. Furthermore, increased ATM …