The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …

Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R)
to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in …

Background Adult-onset severe asthma is characterized by highly symptomatic disease
despite high-intensity asthma treatments. Understanding of the underlying pathways of this …

… Conflict of interest: LJ Fleming reports personal fees for advisory board work from Novartis,
Vectura and Boehringer Ingelheim, grants from Asthma UK and BLF, and personal fees for …

… Fleming contributed to the conception and design of the work, the interpretation of data as
well as drafting the manuscript and revising it. All authors approved the final version of the …

Background The role of IL-17 immunity is well established in patients with inflammatory
diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in …

… Conflict of interest: LJ Fleming has received personal fees for advisory board meetings
from Novartis, Vectura and Boehringer Ingelheim, grants from Asthma UK and BLF, and …

To the Editor: Acute wheeze in preschool children accounts for more than 75% of pediatric
health care attendances for wheeze/asthma in the United Kingdom. 1 The high morbidity …