The constant increase in asthma and atopy prevalences—despite improved treatment and
knowledge of many aspects of the diseases—has raised growing concern. Accumulating …

Irrespective of improved knowledge of many aspects of atopic diseases, the unfavorable trends
in their prevalence particularly among children could not have been reversed. A growing …

Conventional risk factors have been unable to explain most of the substantial increase in
the prevalence of asthma observed in many countries during the last few decades. Much …

… LC Von Hertzen … Data on asthma prevalence obtained from Latvala et al (1), data on
the asphalt index from von Hertzen et al (117) (both left y-axel), and data on proportions of …

… von Hertzen Skin and Allergy Hospital, Helsinki University Central Hospital PO Box 160 …
27 von Hertzen LC: Role of persistent infection in the control and severity of asthma – focus on …

The diverging of T-helper (Th) cells into predominantly Thl and Th2 subsets on the basis of
their cytokine profiles has decisively improved our understanding of the pathogenesis of …

The current unfavourable trends in asthma and atopy prevalences have raised great concern
and have challenged investigators to accelerate search for new risk factors for atopic …

Dysregulated immune function is involved in the pathogenesis of many common human
diseases. Living in urban, microbe-poor environment may have a profound influence on the …

… von Hertzen … von Hertzen … Van der Pouw Kraan, TC, LC Boeije, ER de Groot, SO Stapel,
A. Snijders, ML Kapsenberg, JS van der Zee, and LA AardenReduced production of IL-12 and IL-…

The house dust mite (HDM) monosensitization rates in Finnish and Russian Karelia, two
adjacent areas with fundamentally different lifestyles and living conditions, were determined; …