The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

…, HH Lin, SR Atre, HS Schaaf, KC Chang… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis
remains out of control in several parts of the world including Africa and Asia. Although …

Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis

…, R Centis, PC Chan, ED Chan, KC Chang… - The Lancet, 2018 - thelancet.com
Background Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed
to estimate the association of treatment success and death with the use of individual drugs, …

Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

…, JA Caminero, ACC Carvalho, KC Chang… - 2014 - Eur Respiratory Soc
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis
(TB) substantially challenges TB control, especially in the European Region of the World …

The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions

…, A Esmail, AJ Scott, Z Udwadia, KC Chang… - The Lancet …, 2022 - thelancet.com
The global tuberculosis burden remains substantial, with more than 10 million people newly
ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade, …

Pyrazinamide susceptibility testing in Mycobacterium tuberculosis: a systematic review with meta-analyses

KC Chang, WW Yew, Y Zhang - Antimicrobial agents and …, 2011 - Am Soc Microbiol
Standard culture-based testing of the susceptibility of Mycobacterium tuberculosis to
pyrazinamide is difficult to perform. This systematic review with meta-analyses evaluated the roles …

[HTML][HTML] CISH and Susceptibility to Infectious Diseases

…, A Rautanen, TC Mills, KC Chang… - … England Journal of …, 2010 - Mass Medical Soc
Background The interleukin-2–mediated immune response is critical for host defense against
infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a …

Management of difficult multidrug‐resistant tuberculosis and extensively drug‐resistant tuberculosis: update 2012

KC CHANG, WWAI YEW - Respirology, 2013 - Wiley Online Library
Multidrug‐resistant (MDR) tuberculosis (TB) denotes bacillary resistance to at least isoniazid
and rifampicin. Extensively drug‐resistant (XDR) TB is MDR‐TB with additional bacillary …

The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and …

…, TG Clark, FA Sirgel, HS Schaaf, KC Chang… - The Lancet …, 2019 - thelancet.com
The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was published
in 2017, which comprehensively reviewed and provided recommendations on various …

WHO group 5 drugs and difficult multidrug-resistant tuberculosis: a systematic review with cohort analysis and meta-analysis

KC Chang, WW Yew, CM Tam… - Antimicrobial agents and …, 2013 - Am Soc Microbiol
It is often necessary to include WHO group 5 drugs in the treatment of extensively drug-resistant
tuberculosis (XDR-TB) and fluoroquinolone-resistant multidrug-resistant tuberculosis (…

Oxidative stress and first-line antituberculosis drug-induced hepatotoxicity

WW Yew, KC Chang, DP Chan - Antimicrobial agents and …, 2018 - Am Soc Microbiol
Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant
morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment …