Cellular responses to nanoparticles: target structures and mechanisms

K Unfried, C Albrecht, LO Klotz, A Von Mikecz… - …, 2007 - Taylor & Francis
Nanotechnology makes use of the special surface properties of extremely small particles. In
this rapidly growing field, many different materials are produced for a multitude of diverse …

The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation

…, C Albrecht, J Abel, J Krutmann, K Unfried - American journal of …, 2009 - atsjournals.org
Rationale: Inflammatory reactions of the airways induced by nanoparticles of occupational
and environmental origin contribute to organ-specific and systemic human diseases. Because …

Mitochondrial telomerase reverse transcriptase protects from myocardial ischemia/reperfusion injury by improving complex I composition and function

…, J Greulich, F von Ameln, O Eckermann, K Unfried… - Circulation, 2021 - Am Heart Assoc
Background: The catalytic subunit of telomerase, telomerase reverse transcriptase (TERT),
has protective functions in the cardiovascular system. TERT is not only present in the nucleus …

[HTML][HTML] Digital research data: from analysis of existing standards to a scientific foundation for a modular metadata schema in nanosafety

…, L Mädler, M Razum, C van Thriel, K Unfried… - Particle and fibre …, 2022 - Springer
Background Assessing the safety of engineered nanomaterials (ENMs) is an interdisciplinary
and complex process producing huge amounts of information and data. To make such data …

Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R

…, J Abel, RPF Schins, K Unfried - … of Physiology-Lung …, 2006 - journals.physiology.org
Apoptosis and proliferation are important causes of adverse health effects induced by inhaled
ultrafine particles. The molecular mechanisms of particle cell interactions mediating these …

Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation

…, M Kelm, J Krutmann, K Unfried - European …, 2013 - Eur Respiratory Soc
The life span of neutrophilic granulocytes has a determining impact on the intensity and
duration of neutrophil driven lung inflammation. Based on the compatible solute ectoine, we …

Signal transduction pathways relevant for neoplastic effects of fibrous and non-fibrous particles

C Albrecht, PJA Borm, K Unfried - Mutation Research/Fundamental and …, 2004 - Elsevier
Apart from their genotoxic effects, both fibrous and non-fibrous particles are known to induce
signalling pathways involved in the development of malignant lung diseases. Different …

Carbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent Akt activation

K Unfried, U Sydlik, K Bierhals… - American Journal of …, 2008 - journals.physiology.org
Treatment of lung epithelial cells with different kinds of nano-sized particles leads to cell
proliferation. Because bigger particles fail to induce this reaction, it is suggested that the special …

Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro

…, F Bendt, TC Zschauer, TD Rockel, K Unfried… - Archives of …, 2017 - Springer
Food supplements based on herbal products are widely used during pregnancy as part of a
self-care approach. The idea that such supplements are safe and healthy is deeply seated in …

Distinct Spectrum of Mutations Induced by Crocidolite Asbestos: Clue for 8-Hydroxydeoxyguanosine-dependent Mutagenesis in Vivo

K Unfried, C Schürkes, J Abel - Cancer Research, 2002 - AACR
DNA damage due to reactive oxygen or nitrogen species is proposed to be involved in the
molecular mechanism of asbestos-induced carcinogenicity. However, indications for this …