Natural killer (NK) cells form immune synapses to ascertain the state of health of cells they
encounter. If a target cell triggers NK cell cytotoxicity, lytic granules containing proteins …

TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing
CD226 co-stimulation through interactions in cis or through competition of shared ligands. …

Tumor immune escape is a major factor contributing to cancer progression and unresponsiveness
to cancer therapies. Tumors can produce prostaglandin E 2 (PGE 2 ), an inflammatory …

The base of the cilium comprising the transition zone (TZ) and transition fibers (TF) acts as a
selecting gate to regulate the intraflagellar transport (IFT)-dependent trafficking of proteins to …

Genetic diversity in human natural killer (NK) cell receptors is linked to resistance and
susceptibility to many diseases. Here, we tested the effect of this diversity on the nanoscale …

One of the most obvious manifestations of polarity in epithelia is the subdivision of the cell
surface by cell junctions into apical and basolateral domains. crumbs genes are among key …

Here, we describe a method, which we term “shadow imaging,” to analyze the secretions of
individual cells at immune synapses or other cell contacts. Following immune synapse …

Background: Pneumolysin is the cholesterol dependent pore forming toxin that is released
from Streptococcus pneumoniae during respiratory infection. The release of pneumolysin is …

… Khodor S. Hazime, corresponding author 1 Zhu Zhou, 1 Ewa Joachimiak, 2 Natalia A.
Bulgakova, corresponding author 1 Dorota Wloga, corresponding author 2 and Jarema J …

… Khodor Hazime …