Chemokines direct the trafficking of white blood cells in immune surveillance, playing a key
role in inflammatory and infectious diseases such as AIDS 1–5 . All chemokines studied so …

AN important process in the immune response is the migration of different populations of
lymphocytes at the proper time to sites of antigenic challenge. Although several …

A recently identified chemokine, fractalkine, is a member of the chemokine gene family, which
consists principally of secreted, proinflammatory molecules. Fractalkine is distinguished …

In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined.
During screening of a complementary DNA library generated from activated mouse pro-T …

The relatively recent appreciation of a new class of cytokines, the chemokines, has done
much to enhance our understanding of the extracellular signals involved in the movement of …

Dendritic cells form a system of highly efficient antigen-presenting cells. After capturing
antigen in the periphery, they migrate to lymphoid organs where they present the antigen to T …

Lymphocyte trafficking is an essential process in immune and inflammatory functions which
can be thought to contain at least two main components: adhesion and migration. Whereas …

The chemokine RANTES induced biphasic mobilization of Ca 2+ in T cells. The initial peak,
a transient increase in cytosolic Ca 2+ mediated by a heterotrimeric guanine nucleotide-…

Migration is a basic feature of many cell types in a wide range of species 1 . Since the 1800s,
cell migration has been proposed to occur in the nervous and immune systems 2 , 3 , and …

(Baggiolini et al., 1997). There are now well over 40 char-The known chemokine receptors,
together with their acterized chemokines (some of which are listed in Table respective ligands…