IL-13 and IL-17A gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease

K Kohyama, S Abe, K Kodaira, T Yukawa… - Annals of Allergy …, 2011 - Elsevier
BACKGROUND: The role of interleukin (IL) 13 and IL-17A in aspirin-exacerbated respiratory
disease (AERD) remains unknown. OBJECTIVE: To analyze the IL-13 and IL-17A gene …

Thromboxane A2 receptor+ 795T> C and chemoattractant receptor-homologous molecule expressed on Th2 cells-466T> C gene polymorphisms in patients with …

K Kohyama, M Hashimoto, S Abe… - Molecular …, 2012 - spandidos-publications.com
It is well known that aspirin-exacerbated respiratory disease (AERD) is more common in
women than in men, however, whether gene polymorphisms of the thromboxane A2 receptor (…

Arg16Gly β2-adrenergic receptor gene polymorphism in Japanese patients with aspirin-exacerbated respiratory disease

K Kohyama, S Abe, K Kodaira, T Yukawa… - International archives of …, 2011 - karger.com
Background: There has been no report that investigated β 2-adrenergic receptor (ADRB2)
gene polymorphism in patients with aspirin-exacerbated respiratory disease (AERD). Methods…

Polymorphisms of the CYP2C19 gene in Japanese patients with aspirin-exacerbated respiratory disease

K Kohyama, S Abe, K Kodaira, T Yukawa… - Journal of Allergy and …, 2011 - jacionline.org
To the Editor: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome
characterized by a severe asthma attack after taking aspirin, nonsteroidal anti-inflammatory drugs (…

Phase II study of oral S-1 plus cisplatin with bevacizumab for advanced non-squamous non-small cell lung cancer

…, K Minato, K Sato, T Kazama, S Ishihara, K Kohyama… - Lung Cancer, 2013 - Elsevier
Background We conducted a phase II study to evaluate the efficacy and safety of S-1 plus
cisplatin with bevacizumab followed by maintenance bevacizumab in patients with advanced …

Exogenous S100A4 Protein Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice by Reducing the Levels of Fibroblast Growth Factors

M Watanabe, H Hirata, M Tatewaki, K Kohyama… - 2016 - dmu.repo.nii.ac.jp
Background and objective: The calcium-binding protein S100A4 belongs to the S100 family
and is involved in fibrotic and inflammatory processes, in which tissue remodeling, cell …

Polymorphisms of the vitamin D-binding protein (DBP) gene in Japanese patients with aspirin-exacerbated respiratory disease (AERD)

K Kohyama, A Kohyama, S Abe… - European …, 2014 - Eur Respiratory Soc
AERD is known to represent acute asthmatic attacks by means of ingestion of aspirin and
other non-steroidal anti-inflammatory drug(NSAID).Individuals with AERD are more commonly …

Relevance of measurement of serum periostin for diagnosing bronchial asthma and estimating its lung function abnormalities

K Kohyama, K Izuhara, A Kohyama, K Nakano… - 2012 - Eur Respiratory Soc
Bronchial asthma is diagnosed by combination of presence of characteristic symptoms and
measurement of reversibility of lung function abnormalities. Non-invasive markers such as …

Cultured normal human bronchial epithelial cells may produce collagen type I stimulation with TGF-b

K Kohyama, N Fueki, R Seki, A Kohyama, T Okada… - 2011 - Eur Respiratory Soc
The clinical characteristics of asthma can be logically explained by asthma-specific airway
inflammation and airway remodeling, the details of which have been recently elucidated. …

Risk factors for disseminated intravascular coagulation (DIC) in patients with lung cancer

…, N Yoshida, R Souma, M Tatewaki, K Kohyama… - 2016 - Eur Respiratory Soc
Background: Treatment of DIC in lung cancer (LC) is considered more difficult than in other
lung diseases, but it has not been clarified. Aims: To elucidate the risk factors for DIC in LC, …