User profiles for Kenji Wakabayashi

Kenji Wakabayashi

Professor of Intensive Care Medicine, Tokyo Medical and Dental University
Verified email at tmd.ac.jp
Cited by 315

Purification and some properties of an alkaline xylanase from alkaliphilic Bacillus sp. strain 41M-1

S Nakamura, K Wakabayashi, R Nakai… - Applied and …, 1993 - Am Soc Microbiol
An alkaliphilic Bacillus sp. strain, 41M-1, isolated from soil produced multiple xylanases
extracellularly. One of these xylanases was purified to homogeneity by ammonium sulfate …

[HTML][HTML] Structural basis of digoxin that antagonizes RORγt receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production

…, S Ito, T Isobe, T Ohyama, K Wakabayashi… - Journal of Biological …, 2011 - ASBMB
The retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ2 is well known as a
master regulator of interleukin 17 (IL-17)-producing helper T (Th17) cell development. To …

Platelet‐derived growth factor BB secreted from osteoclasts acts as an osteoblastogenesis inhibitory factor

…, T Nakamura, K Wakabayashi - Journal of Bone and …, 2002 - academic.oup.com
Osteoclasts and osteoblasts are responsible for strict bone maintenance with a balance
between bone formation and resorption by interacting with each other. Recently, it has been …

Glass Transitions of Ordinary and Heavy Water within Silica‐Gel Nanopores

M Oguni, S Maruyama, K Wakabayashi… - Chemistry–An Asian …, 2007 - Wiley Online Library
The dynamic properties of water confined within nanospaces are of interest given that such
water plays important roles in geological and biological systems. The enthalpy‐relaxation …

Possible involvement of IκB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor κB ligand

…, H Nishina, T Katada, K Wakabayashi… - Journal of Bone and …, 2002 - academic.oup.com
Recent studies have revealed the essential role of the receptor activator of nuclear factor κB
(NF‐κB) ligand (RANKL) in osteoclast differentiation and activation. Adenovirus vector could …

Cloning and functional expression of human endothelin-converting enzyme cDNA

K Shimada, Y Matsushita, K Wakabayashi… - Biochemical and …, 1995 - Elsevier
Endothelin (ET) is a 21-residue potent vasoconstrictive peptide produced by vascular
endothelial cells and formed from its precursor, big endothelin (big ET), by endothelin-converting …

Mobilization and margination of bone marrow Gr-1high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury

…, MR Wilson, JO Dokpesi, K Wakabayashi… - The Journal of …, 2009 - journals.aai.org
The specialized role of mouse Gr-1 high monocytes in local inflammatory reactions has
been well documented, but the trafficking and responsiveness of this subset during systemic …

Proteome analysis of secreted proteins during osteoclast differentiation using two different methods: Two‐dimensional electrophoresis and isotope‐coded affinity tags …

K Kubota, K Wakabayashi, T Matsuoka - Proteomics, 2003 - Wiley Online Library
Bone is maintained by two cell types, bone‐forming osteoblasts and bone‐resorbing
osteoclasts. Osteoblasts express two factors, osteoprotegerin and receptor activator of NF‐κB …

Volutrauma, but not atelectrauma, induces systemic cytokine production by lung-marginated monocytes

K Wakabayashi, MR Wilson, KC Tatham… - Critical care …, 2014 - journals.lww.com
Objectives: Ventilator-induced lung injury has substantive impact on mortality of patients with
acute respiratory distress syndrome. Although low tidal volume ventilation has been shown …

Effectiveness of remdesivir with corticosteroids for COVID‐19 patients in intensive care unit: A hospital‐based observational study

…, Y Ueki, N Nosaka, K Wakabayashi… - Journal of medical …, 2023 - Wiley Online Library
The effectiveness of remdesivir on survival in coronavirus disease 2019 (COVID‐19),
especially in cases treated in the intensive care unit (ICU), is controversial. We investigated the …