[HTML][HTML] Endothelium-dependent hyperpolarization (EDH) in hypertension: the role of endothelial ion channels

K Goto, T Ohtsubo, T Kitazono - International Journal of Molecular …, 2018 - mdpi.com
Upon stimulation with agonists and shear stress, the vascular endothelium of different vessels
selectively releases several vasodilator factors such as nitric oxide and prostacyclin. In …

[HTML][HTML] Endothelium-dependent hyperpolarization (EDH) in diabetes: mechanistic insights and therapeutic implications

K Goto, T Kitazono - International journal of molecular sciences, 2019 - mdpi.com
Diabetes mellitus is one of the major risk factors for cardiovascular disease and is an important
health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn …

Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired …

T Seki, K Goto, K Kiyohara, Y Kansui, N Murakami… - …, 2017 - Am Heart Assoc
Endothelium-dependent hyperpolarization (EDH)–mediated responses are impaired in
hypertension, but the underlying mechanisms have not yet been determined. The activation of …

Attenuation of conducted vasodilatation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels

K Goto, NM Rummery, TH Grayson… - The Journal of …, 2004 - Wiley Online Library
The present study was designed to elucidate whether the conduction of vasomotor responses
mediated by endothelium‐derived hyperpolarizing factor (EDHF) in rat mesenteric arteries …

[HTML][HTML] The transient receptor potential vanilloid 4 channel and cardiovascular disease risk factors

K Goto, T Kitazono - Frontiers in Physiology, 2021 - frontiersin.org
Vascular endothelial cells regulate arterial tone through the release of nitric oxide and other
diffusible factors such as prostacyclin and endothelium derived hyperpolarizing factors. …

Angiotensin II receptor–neprilysin inhibitor sacubitril/valsartan improves endothelial dysfunction in spontaneously hypertensive rats

T Seki, K Goto, Y Kansui, T Ohtsubo… - Journal of the …, 2017 - Am Heart Assoc
Background We have previously demonstrated that antihypertensive treatment with renin‐angiotensin
system inhibitors restores the impaired endothelium‐dependent hyperpolarization …

[HTML][HTML] Chloride ions, vascular function and hypertension

K Goto, T Kitazono - Biomedicines, 2022 - mdpi.com
Blood pressure is determined by cardiac output and systemic vascular resistance, and
mediators that induce vasoconstriction will increase systemic vascular resistance and thus …

Non‐linear relationship between hyperpolarisation and relaxation enables long distance propagation of vasodilatation

SE Wölfle, DJ Chaston, K Goto… - The Journal of …, 2011 - Wiley Online Library
Non‐technical summary Microvascular dilatations initiated locally in metabolically active
tissues spread rapidly upstream, with little attenuation, to larger vessels whose relaxation …

Renin-angiotensin system blockade improves endothelial dysfunction in hypertension

K Goto, K Fujii, U Onaka, I Abe, M Fujishima - Hypertension, 2000 - Am Heart Assoc
Angiotensin-converting enzyme (ACE) inhibitor improves the impaired hyperpolarization and
relaxation to acetylcholine (ACh) via endothelium-derived hyperpolarizing factor (EDHF) in …

Small dense low-density lipoprotein cholesterol and the risk of coronary heart disease in a Japanese community

…, D Yoshida, Y Hirakawa, M Shibata, K Goto… - … of atherosclerosis and …, 2020 - jstage.jst.go.jp
Aims: This study aims to investigate the association between serum small dense low-density
lipoprotein (sdLDL) cholesterol level and the development of coronary heart disease (CHD) …