[HTML][HTML] Mechanisms of telomere loss and their consequences for chromosome instability

K Muraki, K Nyhan, L Han, JP Murnane - Frontiers in oncology, 2012 - frontiersin.org
The ends of chromosomes in mammals, called telomeres, are composed of a 6-bp repeat
sequence, TTAGGG, which is added on by the enzyme telomerase. In combination with a …

[HTML][HTML] Hydration with magnesium and mannitol without furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non …

K Muraki, R Koyama, Y Honma, S Yagishita… - Journal of thoracic …, 2012 - ncbi.nlm.nih.gov
Background The aim of this study was to examine the effect of hydration with magnesium
and mannitol without furosemide on the nephrotoxocity accompanying combination …

[HTML][HTML] Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease

…, K Suina, T Asao, R Kanemaru, Y Honma, K Muraki… - Bmc Cancer, 2014 - Springer
Background Non-small cell lung cancer (NSCLC) patients with interstitial lung disease (ILD)
need to be approached carefully given the high incidence of pulmonary toxicity. Pemetrexed …

[HTML][HTML] The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line

K Muraki, L Han, D Miller, JP Murnane - PLoS genetics, 2013 - journals.plos.org
Telomeres distinguish chromosome ends from double-strand breaks (DSBs) and prevent
chromosome fusion. However, telomeres can also interfere with DNA repair, as shown by a …

Prognostic factors and efficacy of first‐line chemotherapy in patients with advanced thymic carcinoma: A retrospective analysis of 286 patients from NEJ023 study

…, A Fujiwara, T Sugiyama, K Azuma, K Muraki… - The …, 2018 - academic.oup.com
Background The prognostic factors and the efficacy of first‐line chemotherapy remain unclear
in patients with advanced thymic carcinoma. Materials and Methods We conducted a multi‐…

The DNA damage response at dysfunctional telomeres, and at interstitial and subtelomeric DNA double-strand breaks

K Muraki, JP Murnane - Genes & genetic systems, 2017 - jstage.jst.go.jp
In mammals, DNA double-strand breaks (DSBs) are primarily repaired by classical non-homologous
end joining (C-NHEJ), although homologous recombination repair and alternative …

[HTML][HTML] Cerebral infarction in advanced non-small cell lung cancer: a case control study

…, K Mori, R Kanemaru, Y Honma, Y Nanjo, K Muraki… - BMC cancer, 2016 - Springer
Background Advanced non-small cell lung cancer (NSCLC) patients often develop
thromboembolic events, including cerebral infarction (CI). However, the relationship between …

Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks

K Muraki, L Han, D Miller, JP Murnane - Nucleic acids research, 2015 - academic.oup.com
The caps on the ends of chromosomes, called telomeres, keep the ends of chromosomes
from appearing as DNA double-strand breaks (DSBs) and prevent chromosome fusion. …

Cell‐cycle‐dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo‐like kinase

A Nishiyama, K Muraki, M Saito, K Ohsumi… - The EMBO …, 2006 - embopress.org
Telomeres are regulated by a homeostatic mechanism that includes telomerase and
telomeric repeat binding proteins, TRF1 and TRF2. Recently, it has been hypothesized that …

Efficacy and safety of platinum combination chemotherapy re-challenge for relapsed patients with non-small-cell lung cancer after postoperative adjuvant …

H Imai, T Shukuya, R Yoshino, K Muraki, K Mori… - Chemotherapy, 2014 - karger.com
Background: There is no standard therapy for relapsed patients who have received
postoperative platinum-based adjuvant chemotherapy for resected non-small-cell lung cancer (…