Triggering innate immune responses through TLRs is expected to be a novel therapeutic
strategy for the treatment of allergic diseases. TLR agonists are able to modulate Th2 immune …

Toll-like receptors (TLRs) play important roles in the innate immune system. In fact, recognition
of endogenous immune complexes containing self-nucleic acids as pathogen- or damage…

Nitrogen starvation-mediated reduction of Ypk1 is suggested to suppress translational initiation,
possibly in parallel with the target of rapamycin complex 1 (TORC1) signaling. However, …

AZD8848/DSP-3025 was administered weekly via the route either prophylactically or
therapeutically into a 3 METHODS: intranasal times-weekly OVA challenge A/J mouse model. …

METHODS: inhibiting IL-13 release using lung draining lymph node cells from ovalbumin-sensitised
and challenged BN rats,. Pharmacokinetic in vitro profiling assessed the rapidity of …

Rationale: To identify the mechanisms by which a novel antedrug Toll like receptor 7 (TLR7)
agonist, AZ12441970, mediates the long-lasting suppression of Th2 immune responses. …

RATIONALE: with acute or weekly dosing, in the prevention of airway obstruction and other
markers of pulmonary inflammation in mechanistic and allergen challenge models of allergic …

Results: shows substantially less activity than the parent compound. The active ante-drug has
a biological profile similar to that of other known TLR7 agonists with induction of a range of …

Results: PBMCs and mouse splenocyes TLR7 agonists induce IFNα from plasmacytoid
dendritic cells and this cytokine was shown to be in vitro. important in mediating the inhibition of …

… Mitsugu Shimobayashi, Hiromu Takematsu, Kazuo Eiho, Yukari Yamane, Shinsuke
Hiramoto, Yasunori Kozutsumi …