Long-term safety, efficacy, pharmacokinetics and pharmacodynamics of omalizumab in children with severe uncontrolled asthma

…, K Kurihara, T Teramoto, K Sugai… - Allergology …, 2017 - jstage.jst.go.jp
Background: Omalizumab is effective and well-tolerated in children with moderate to severe
allergic asthma. However, the effects of long-term treatment with omalizumab in this …

Omalizumab in Japanese children with severe allergic asthma uncontrolled with standard therapy

…, T Katsunuma, K Kurihara, N Kondo, K Sugai… - Allergology …, 2015 - jstage.jst.go.jp
Background: Omalizumab has demonstrated clinical benefits in children with moderate to
severe allergic asthma. However, no studies have been performed in Japanese asthmatic …

Genetic analysis of attachment glycoprotein (G) gene in new genotype ON1 of human respiratory syncytial virus detected in Japan

…, M Noda, N Yamamoto, K Sugai… - Microbiology and …, 2013 - Wiley Online Library
We studied the evolution of the G gene in the new genotype ON1 of RSV detected from
patients with acute respiratory infection in Japan. Phylogenetic analyses and the evolutionary …

Acute allergic reaction due to milk proteins contaminating lactose added to corticosteroid for injection

A Eda, K Sugai, H Shioya, A Fujitsuka, S Ito… - Allergology …, 2009 - jstage.jst.go.jp
We encountered two patients with severe cow’s milk allergy who reacted strongly to an injection
of methylprednisolone sodium succinate (Sol-Medrol 40 mgⓇ Pfizer, Japan). They came …

[HTML][HTML] Evaluation of oral immunotherapy efficacy and safety by maintenance dose dependency: a multicenter randomized study

…, N Kondo, A Urisu, I Tsuge, Y Kondo, K Sugai… - World Allergy …, 2020 - Elsevier
Background Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the
efficacy of treatment with OIT at a low dose has been reported. However, the optimal dose …

Identification of biomarkers for predicting the response to cyclosporine A therapy in patients with chronic spontaneous urticaria

…, S Izaki, N Nishimori, M Ito, K Sugai… - Allergology …, 2019 - jstage.jst.go.jp
Cyclosporine A (CsA) is recommended as a third-line treatment for patients with chronic
urticaria (CU) in the guideline of the European Academy of Allergy and Clinical Immunology (…

[HTML][HTML] Molecular evolution of the VP1, VP2 and VP3 genes in human rhinovirus species C

…, T Kusaka, N Shimojo, S Hasegawa, K Sugai… - Scientific Reports, 2015 - nature.com
Human rhinovirus species C (HRV-C) was recently discovered and this virus has been
associated with various acute respiratory illnesses (ARI). However, the molecular evolution of the …

Predictive values of egg‐specific IgE by two commonly used assay systems for the diagnosis of egg allergy in young children: a prospective multicenter study

…, C Tatsumoto, T Fukuie, R Yasuoka, M Ikeda, K Sugai… - Allergy, 2016 - Wiley Online Library
Background Specific IgE ( sIgE ) is often used to predict oral food challenge ( OFC ) outcomes
in food allergy, but interpretation of the results may vary depending on the assay method …

MIP-1α level in nasopharyngeal aspirates at the first wheezing episode predicts recurrent wheezing

K Sugai, H Kimura, Y Miyaji, H Tsukagoshi… - Journal of Allergy and …, 2016 - Elsevier
Background Respiratory virus–induced wheezing, such as that induced by respiratory syncytial
virus (RSV) and human rhinovirus, is an important risk factor for recurrent wheezing and …

Severity of respiratory signs and symptoms and virus profiles in Japanese children with acute respiratory illness

Y Miyaji, M Kobayashi, K Sugai… - Microbiology and …, 2013 - Wiley Online Library
Associations between the severity of respiratory signs and symptoms and the respiratory
viruses identified in 214 Japanese children with acute respiratory illness (ARI) enrolled …