Murine NKT cells produce Th17 cytokine interleukin-22

…, K Kadoshima-Yamaoka, Y Tanaka, K Nagahira… - Cellular …, 2009 - Elsevier
Natural killer T (NKT) cells are known to produce Th17 cytokine IL-17 in addition to Th1/2
cytokines. In this study, the ability of NKT cells to produce IL-22, another Th17 cytokine, was …

Design, Synthesis, and Biological Evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as New Indole-Based Cytosolic Phospholipase A2α Inhibitors

…, Y Fujieda, M Terakawa, K Nagahira - Journal of medicinal …, 2014 - ACS Publications
This article describes the design, synthesis, and biological evaluation of new indole-based
cytosolic phospholipase A 2 α (cPLA 2 α, a group IVA phospholipase A 2 ) inhibitors. A …

ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-γ production by mouse activated T lymphocytes

…, H Murafuji, A Nagahira, Y Hayashi, K Nagahira… - Immunology letters, 2009 - Elsevier
Phosphodiesterase 7A (PDE7A) has been suggested to be involved in activation of T
lymphocytes. In the present study, a possible involvement of PDE7A in function of preactivated T …

ASB14780, an orally active inhibitor of group IVA phospholipase A2, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease

…, K Ishihara, E Kawashita, T Tomoo, K Nagahira… - … of Pharmacology and …, 2016 - ASPET
We have previously shown that high-fat cholesterol diet (HFCD)–induced fatty liver and carbon
tetrachloride (CCl 4 )–induced hepatic fibrosis are reduced in mice deficient in group IVA …

[HTML][HTML] Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single …

…, R Nakamura, M Terakawa, S Muneoka, K Nagahira… - PloS one, 2017 - journals.plos.org
The majority of patients with myasthenia gravis (MG), an organ-specific autoimmune disease,
harbor autoantibodies that attack the nicotinic acetylcholine receptor (nAChR-Abs) at the …

Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells

…, Y Hayashi, K Miura, T Nakatsuka, K Nagahira… - Cellular …, 2009 - Elsevier
A possible involvement of phosphodiesterase 7A (PDE7A) in proliferation and function of
NKT cells was examined using ASB16165, a selective inhibitor for PDE7A. Stimulation of …

Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis

…, T Muto, T Tanaka, H Maruoka, K Nagahira… - European journal of …, 2008 - Elsevier
Chymase is a chymotrypsin-like serine protease exclusively stored in secretory granules of
mast cells and has been thought to participate in allergic diseases. It has already been …

Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo

…, H Murafuji, S Kanki, Y Hayashi, K Nagahira… - European journal of …, 2010 - Elsevier
Excessive proliferation of epidermal keratinocytes is a typical aspect of chronic skin
diseases such as psoriasis. In the present study, the effect of phosphodiesterase 7A (PDE7A) …

Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte

…, H Inoue, H Murafuji, Y Hayashi, K Nagahira… - International …, 2009 - Elsevier
In the present study, possible role of phosphodiesterase 7 (PDE7) in development and function
of cytotoxic T lymphocyte (CTL) was examined using ASB16165, a specific inhibitor for …

Fucoidin, a potent inhibitor of L-selectin function, reduces contact hypersensitivity reaction in mice

T Nasu, Y Fukuda, K Nagahira, H Kawashima… - Immunology letters, 1997 - Elsevier
In order to investigate the role of l-selectin (CD62L) in delayed-type hypersensitivity (DTH)
reaction, effect of fucoidin, a potent inhibitor of CD62L function, was examined in a model of …