User profiles for Kazuhiro Ito
 | Kazuhiro ItoProfessor (PRF) of Respiratory Molecular Pharmacology in Imperial College Verified email at imperial.ac.uk Cited by 30062 |
[HTML][HTML] Decreased histone deacetylase activity in chronic obstructive pulmonary disease
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
airway inflammation that is greater in patients with advanced disease. We asked whether there …
airway inflammation that is greater in patients with advanced disease. We asked whether there …
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown,
but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling …
but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling …
Accelerated ageing of the lung in COPD: new concepts
The rise in life expectancy worldwide has been accompanied by an increased incidence of
age-related diseases, representing an enormous burden on healthcare services and society. …
age-related diseases, representing an enormous burden on healthcare services and society. …
Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
Glucocorticoids are the most effective antiinflammatory agents for the treatment of chronic
inflammatory diseases even though some diseases, such as chronic obstructive pulmonary …
inflammatory diseases even though some diseases, such as chronic obstructive pulmonary …
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12
We have investigated the ability of dexamethasone to regulate interleukin-1β (IL-1β)-induced
gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity…
gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity…
COPD as a disease of accelerated lung aging
There is increasing evidence for a close relationship between aging and chronic inflammatory
diseases. COPD is a chronic inflammatory disease of the lungs, which progresses very …
diseases. COPD is a chronic inflammatory disease of the lungs, which progresses very …
Trichostatin A Is a Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vivo
Purpose: Trichostatin A (TSA), an antifungal antibiotic with cytostatic and differentiating
properties in mammalian cell culture, is a potent and specific inhibitor of histone deacetylase (…
properties in mammalian cell culture, is a potent and specific inhibitor of histone deacetylase (…
Update on glucocorticoid action and resistance
Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic exposure…
molecules that have been optimized to target activity to the lung and minimize systemic exposure…
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages
Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease
of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. …
of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. …
Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
By contrast with patients with asthma, those with chronic obstructive pulmonary disease (COPD)
are poorly responsive to the anti-inflammatory actions of corticosteroids, and these …
are poorly responsive to the anti-inflammatory actions of corticosteroids, and these …