Airflow limitation and airway dimensions in chronic obstructive pulmonary disease

…, Y Onodera, H Makita, K Nagai… - American journal of …, 2006 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow
limitation caused by emphysema and/or airway narrowing. Computed tomography has been …

Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease

M Nishimura, H Makita, K Nagai, S Konno… - American journal of …, 2012 - atsjournals.org
Rationale: Although the rate of annual decline in FEV 1 is one of the most important
outcome measures in chronic obstructive pulmonary disease (COPD), little is known about …

Down-regulated NF-E2–related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease

M Suzuki, T Betsuyaku, Y Ito, K Nagai… - American journal of …, 2008 - atsjournals.org
Pulmonary macrophages are one of the sources of various antioxidant and detoxification
enzymes for which NF-E2–related factor 2 (Nrf2) is a key transcriptional factor. Although Nrf2 …

Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease

H Makita, Y Nasuhara, K Nagai, Y Ito, M Hasegawa… - Thorax, 2007 - thorax.bmj.com
Background: Airflow limitation in chronic obstructive pulmonary disease (COPD) is caused by
a mixture of small airway disease and emphysema, the relative contributions of which may …

Clinical features and determinants of COPD exacerbation in the Hokkaido COPD cohort study

M Suzuki, H Makita, YM Ito, K Nagai… - European …, 2014 - Eur Respiratory Soc
Exacerbations are among the major factors that may affect the natural history of chronic
obstructive pulmonary disease (COPD). The aim was to investigate the clinical characteristics …

Curcumin attenuates elastase-and cigarette smoke-induced pulmonary emphysema in mice

M Suzuki, T Betsuyaku, Y Ito, K Nagai… - … of Physiology-Lung …, 2009 - journals.physiology.org
Curcumin, a yellow pigment obtained from turmeric (Curcumina longa), is a dietary polyphenol
that has been reported to possess anti-inflammatory and antioxidant properties. The …

Distinct phenotypes of smokers with fixed airflow limitation identified by cluster analysis of severe asthma

…, H Kimura, Y Maeda, M Suzuki, K Nagai… - Annals of the …, 2018 - atsjournals.org
Rationale: Smoking may have multifactorial effects on asthma phenotypes, particularly in
severe asthma. Cluster analysis has been applied to explore novel phenotypes, which are not …

[HTML][HTML] The role of catalase in pulmonary fibrosis

N Odajima, T Betsuyaku, K Nagai, C Moriyama… - Respiratory …, 2010 - Springer
Background Catalase is preferentially expressed in bronchiolar and alveolar epithelial cells,
and acts as an endogenous antioxidant enzyme in normal lungs. We thus postulated …

β2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD

…, H Makita, Y Nasuhara, T Betsuyaku, Y Itoh, K Nagai… - Chest, 2007 - Elsevier
Background COPD is characterized by a persistent airflow limitation that is not fully reversible;
thus, the reversibility of airflow limitations in response to a bronchodilator is an important …

Efficacy and safety of long-term sirolimus therapy for Asian patients with lymphangioleiomyomatosis

…, N Kitamura, K Seyama, Y Inoue, K Nagai… - Annals of the …, 2016 - atsjournals.org
Rationale: Sirolimus has been shown in a randomized, controlled clinical trial to stabilize
lung function in patients with lymphangioleiomyomatosis (LAM) treated for a 12-month time …