Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing

…, RJ Farney, SM Rhondeau, KM Boyle… - Journal of Clinical …, 2007 - jcsm.aasm.org
Background: Chronic opioid therapy for pain management has increased dramatically
without adequate study of potential deleterious effects on breathing during sleep. Methods: A …

Amyloid-β peptide binds with heme to form a peroxidase: Relationship to the cytopathologies of Alzheimer's disease

H Atamna, K Boyle - … of the National Academy of Sciences, 2006 - National Acad Sciences
Amyloid-β peptide (Aβ) is the toxic agent in Alzheimer’s disease (AD), although the mechanism
causing the neurodegeneration is not known. We previously proposed a mechanism in …

Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways

H Atamna, A Nguyen, C Schultz, K Boyle… - The FASEB …, 2008 - Wiley Online Library
Methylene blue (MB) has been used clinically for about a century to treat numerous ailments.
We show that MB and other diaminophenothia‐zines extend the life span of human IMR90 …

In vitro antifungal activities of voriconazole and reference agents as determined by NCCLS methods: review of the literature

A Espinel-Ingroff, K Boyle, DJ Sheehan - Mycopathologia, 2001 - Springer
Voriconazole (Vfend™) is a new triazole that currently is undergoing phase III clinical trials.
This review summarizes the published data obtained by NCCLS methods on the in vitro …

[HTML][HTML] Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation

PA Linden, RJ Gilbert, BY Yeap, K Boyle… - The Journal of Thoracic …, 2006 - Elsevier
OBJECTIVE: There is a strong association between reflux and end-stage lung disease,
especially idiopathic pulmonary fibrosis. The presence of reflux after lung transplantation might …

Mitochondria-targeted analogues of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells

…, J Zielonka, O Ouari, M Lopez, D McAllister, K Boyle… - Cancer research, 2016 - AACR
Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in
cancer treatment based on recent evidence of its apparent chemopreventive properties. Met …

Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway

KA Boyle, RL Pietropaolo… - Molecular and cellular …, 1999 - Taylor & Francis
Cells respond to contact with human cytomegalovirus (HCMV) virions by initiating intracellular
signaling and gene expression characteristic of the interferon (IFN)-responsive pathway. …

Development of professional identity through socialization in graduate school

…, K Pasquesi, AS Hirschy, KM Boyle - Journal of Student …, 2014 - Taylor & Francis
Professional identity is one outcome of successful socialization. The purpose of this study
was to understand how socialization in graduate programs contributes to the development of …

Receptor-binding properties of a soluble form of human cytomegalovirus glycoprotein B

KA Boyle, T Compton - Journal of virology, 1998 - Am Soc Microbiol
The human cytomegalovirus (HCMV) glycoprotein B (gB) (also known as gpUL55) homolog
is an important mediator of virus entry and cell-to-cell dissemination of infection. To examine …

[HTML][HTML] Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

KR Simonetta, J Taygerly, K Boyle, SE Basham… - Nature …, 2019 - nature.com
Protein–protein interactions (PPIs) governing the recognition of substrates by E3 ubiquitin
ligases are critical to cellular function. There is significant therapeutic potential in the …