Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing
…, RJ Farney, SM Rhondeau, KM Boyle… - Journal of Clinical …, 2007 - jcsm.aasm.org
Background: Chronic opioid therapy for pain management has increased dramatically
without adequate study of potential deleterious effects on breathing during sleep. Methods: A …
without adequate study of potential deleterious effects on breathing during sleep. Methods: A …
Amyloid-β peptide binds with heme to form a peroxidase: Relationship to the cytopathologies of Alzheimer's disease
H Atamna, K Boyle - … of the National Academy of Sciences, 2006 - National Acad Sciences
Amyloid-β peptide (Aβ) is the toxic agent in Alzheimer’s disease (AD), although the mechanism
causing the neurodegeneration is not known. We previously proposed a mechanism in …
causing the neurodegeneration is not known. We previously proposed a mechanism in …
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
H Atamna, A Nguyen, C Schultz, K Boyle… - The FASEB …, 2008 - Wiley Online Library
Methylene blue (MB) has been used clinically for about a century to treat numerous ailments.
We show that MB and other diaminophenothia‐zines extend the life span of human IMR90 …
We show that MB and other diaminophenothia‐zines extend the life span of human IMR90 …
In vitro antifungal activities of voriconazole and reference agents as determined by NCCLS methods: review of the literature
A Espinel-Ingroff, K Boyle, DJ Sheehan - Mycopathologia, 2001 - Springer
Voriconazole (Vfend™) is a new triazole that currently is undergoing phase III clinical trials.
This review summarizes the published data obtained by NCCLS methods on the in vitro …
This review summarizes the published data obtained by NCCLS methods on the in vitro …
[HTML][HTML] Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation
PA Linden, RJ Gilbert, BY Yeap, K Boyle… - The Journal of Thoracic …, 2006 - Elsevier
OBJECTIVE: There is a strong association between reflux and end-stage lung disease,
especially idiopathic pulmonary fibrosis. The presence of reflux after lung transplantation might …
especially idiopathic pulmonary fibrosis. The presence of reflux after lung transplantation might …
Mitochondria-targeted analogues of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells
Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in
cancer treatment based on recent evidence of its apparent chemopreventive properties. Met …
cancer treatment based on recent evidence of its apparent chemopreventive properties. Met …
Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway
KA Boyle, RL Pietropaolo… - Molecular and cellular …, 1999 - Taylor & Francis
Cells respond to contact with human cytomegalovirus (HCMV) virions by initiating intracellular
signaling and gene expression characteristic of the interferon (IFN)-responsive pathway. …
signaling and gene expression characteristic of the interferon (IFN)-responsive pathway. …
Development of professional identity through socialization in graduate school
…, K Pasquesi, AS Hirschy, KM Boyle - Journal of Student …, 2014 - Taylor & Francis
Professional identity is one outcome of successful socialization. The purpose of this study
was to understand how socialization in graduate programs contributes to the development of …
was to understand how socialization in graduate programs contributes to the development of …
Receptor-binding properties of a soluble form of human cytomegalovirus glycoprotein B
KA Boyle, T Compton - Journal of virology, 1998 - Am Soc Microbiol
The human cytomegalovirus (HCMV) glycoprotein B (gB) (also known as gpUL55) homolog
is an important mediator of virus entry and cell-to-cell dissemination of infection. To examine …
is an important mediator of virus entry and cell-to-cell dissemination of infection. To examine …
[HTML][HTML] Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
KR Simonetta, J Taygerly, K Boyle, SE Basham… - Nature …, 2019 - nature.com
Protein–protein interactions (PPIs) governing the recognition of substrates by E3 ubiquitin
ligases are critical to cellular function. There is significant therapeutic potential in the …
ligases are critical to cellular function. There is significant therapeutic potential in the …