Role for NLRP3 inflammasome–mediated, IL-1β–dependent responses in severe, steroid-resistant asthma
…, AT Essilfie, AAB Robertson, KJ Baines… - American journal of …, 2017 - atsjournals.org
Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
BACKGROUND: Previous studies have identified clinical or inflammatory phenotypes of
asthma on the basis of clinical and demographic parameters or sputum cell counts; however, …
asthma on the basis of clinical and demographic parameters or sputum cell counts; however, …
The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
Background The role of systemic inflammation in asthma is unclear. The aim of this study
was to compare systemic inflammation in subjects with stable asthma, categorized by airway …
was to compare systemic inflammation in subjects with stable asthma, categorized by airway …
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
JL Simpson, S Phipps, KJ Baines… - European …, 2014 - Eur Respiratory Soc
Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is thought
to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of …
to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of …
[HTML][HTML] Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis
…, BS Berthon, ME Jensen, KJ Baines… - The American journal of …, 2017 - Elsevier
Background Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to
produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflammatory …
produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflammatory …
Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
… Author links open overlay panel Katherine J. Baines PhD a b , Jodie L. Simpson PhD a b ,
Lisa G. Wood PhD a b , Rodney J. Scott PhD c , Naomi L. Fibbens DipPathTech a b , Heather …
Lisa G. Wood PhD a b , Rodney J. Scott PhD c , Naomi L. Fibbens DipPathTech a b , Heather …
Neutrophil extracellular traps are associated with inflammation in chronic airway disease
Background and objective Neutrophil extracellular traps ( NETs ) are web‐like structures
comprising DNA and antimicrobial proteins, expelled from neutrophils during NET osis. …
comprising DNA and antimicrobial proteins, expelled from neutrophils during NET osis. …
Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma
JL Simpson, J Daly, KJ Baines, IA Yang… - European …, 2016 - Eur Respiratory Soc
Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists
of chronic inflammation. Little is known about the relation of airway inflammation to the …
of chronic inflammation. Little is known about the relation of airway inflammation to the …
Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD
NA Negewo, VM McDonald, KJ Baines… - … journal of chronic …, 2016 - Taylor & Francis
Introduction Sputum eosinophilia occurs in approximately one-third of stable chronic obstructive
pulmonary disease (COPD) patients and can predict exacerbation risk and response to …
pulmonary disease (COPD) patients and can predict exacerbation risk and response to …
[HTML][HTML] Soluble fibre meal challenge reduces airway inflammation and expression of GPR43 and GPR41 in asthma
I Halnes, KJ Baines, BS Berthon, LK MacDonald-Wicks… - Nutrients, 2017 - mdpi.com
Short chain fatty acids (SCFAs) are produced following the fermentation of soluble fibre by
gut bacteria. In animal models, both dietary fibre and SCFAs have demonstrated anti-…
gut bacteria. In animal models, both dietary fibre and SCFAs have demonstrated anti-…