Role for NLRP3 inflammasome–mediated, IL-1β–dependent responses in severe, steroid-resistant asthma

…, AT Essilfie, AAB Robertson, KJ Baines… - American journal of …, 2017 - atsjournals.org
Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …

Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples

KJ Baines, JL Simpson, LG Wood, RJ Scott… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Previous studies have identified clinical or inflammatory phenotypes of
asthma on the basis of clinical and demographic parameters or sputum cell counts; however, …

The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma

LG Wood, KJ Baines, J Fu, HA Scott, PG Gibson - Chest, 2012 - Elsevier
Background The role of systemic inflammation in asthma is unclear. The aim of this study
was to compare systemic inflammation in subjects with stable asthma, categorized by airway …

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

JL Simpson, S Phipps, KJ Baines… - European …, 2014 - Eur Respiratory Soc
Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is thought
to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of …

[HTML][HTML] Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis

…, BS Berthon, ME Jensen, KJ Baines… - The American journal of …, 2017 - Elsevier
Background Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to
produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflammatory …

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

KJ Baines, JL Simpson, LG Wood, RJ Scott… - Journal of allergy and …, 2014 - Elsevier
… Author links open overlay panel Katherine J. Baines PhD a b , Jodie L. Simpson PhD a b ,
Lisa G. Wood PhD a b , Rodney J. Scott PhD c , Naomi L. Fibbens DipPathTech a b , Heather …

Neutrophil extracellular traps are associated with inflammation in chronic airway disease

…, JL Simpson, VM McDonald, LG Wood, KJ Baines - …, 2016 - Wiley Online Library
Background and objective Neutrophil extracellular traps ( NETs ) are web‐like structures
comprising DNA and antimicrobial proteins, expelled from neutrophils during NET osis. …

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma

JL Simpson, J Daly, KJ Baines, IA Yang… - European …, 2016 - Eur Respiratory Soc
Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists
of chronic inflammation. Little is known about the relation of airway inflammation to the …

Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD

NA Negewo, VM McDonald, KJ Baines… - … journal of chronic …, 2016 - Taylor & Francis
Introduction Sputum eosinophilia occurs in approximately one-third of stable chronic obstructive
pulmonary disease (COPD) patients and can predict exacerbation risk and response to …

[HTML][HTML] Soluble fibre meal challenge reduces airway inflammation and expression of GPR43 and GPR41 in asthma

I Halnes, KJ Baines, BS Berthon, LK MacDonald-Wicks… - Nutrients, 2017 - mdpi.com
Short chain fatty acids (SCFAs) are produced following the fermentation of soluble fibre by
gut bacteria. In animal models, both dietary fibre and SCFAs have demonstrated anti-…