The role of the small airways in the clinical expression of asthma in adults
…, SR Downie, JA Kermode, KM Hardaker… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: The clinical relevance of increased ventilation heterogeneity, a marker of
small-airways disease, in asthmatic patients is unclear. Ventilation heterogeneity is an …
small-airways disease, in asthmatic patients is unclear. Ventilation heterogeneity is an …
Obesity is a determinant of asthma control independent of inflammation and lung mechanics
Background It is unclear why obesity is associated with worse asthma control. We hypothesized
that (1) obesity affects asthma control independent of spirometry, airway inflammation, …
that (1) obesity affects asthma control independent of spirometry, airway inflammation, …
Overdiagnosis of COPD in subjects with unobstructed spirometry: a BOLD analysis
Background There are several reports on underdiagnosis of COPD, while little is known
about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the …
about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the …
[HTML][HTML] A systematic approach to multiple breath nitrogen washout test quality
…, C Saunders, PD Robinson, H Webster, K Hardaker… - PloS one, 2016 - journals.plos.org
Background Accurate estimates of multiple breath washout (MBW) outcomes require correct
operation of the device, appropriate distraction of the subject to ensure they breathe in a …
operation of the device, appropriate distraction of the subject to ensure they breathe in a …
Predictors of airway hyperresponsiveness differ between old and young patients with asthma
KM Hardaker, SR Downie, JA Kermode, CS Farah… - Chest, 2011 - Elsevier
Background Age-related increases in morbidity and mortality due to asthma may be due to
changes in pathophysiology as patients with asthma get older. There is limited knowledge …
changes in pathophysiology as patients with asthma get older. There is limited knowledge …
Association between peripheral airway function and neutrophilic inflammation in asthma
CS Farah, LAB Keulers, KM Hardaker, MJ Peters… - …, 2015 - Wiley Online Library
Background and objective Small airway dysfunction is associated with asthma severity and
control, but its association with airway inflammation is unknown. The aim was to determine …
control, but its association with airway inflammation is unknown. The aim was to determine …
Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts
…, VE Murphy, PD Robinson, K Jesson, K Hardaker… - Thorax, 2021 - thorax.bmj.com
Rationale Asthma in pregnancy is associated with respiratory diseases in the offspring.
Objective To investigate if maternal asthma is associated with lung function in early life. Methods …
Objective To investigate if maternal asthma is associated with lung function in early life. Methods …
Home-based forced oscillation technique day-to-day variability in pediatric asthma
A Wong, K Hardaker, P Field… - American Journal of …, 2019 - atsjournals.org
Methods Enrollment for this study targeted children 8–18 years of age with physician-diagnosed
persistent asthma and two or more exacerbations in the preceding 12 months. After …
persistent asthma and two or more exacerbations in the preceding 12 months. After …
[HTML][HTML] Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross …
…, G Marks, T Bird, P Espinel, K Hardaker… - …, 2024 - thelancet.com
Background Chronic cough is a common respiratory symptom with an impact on daily activities
and quality of life. Global prevalence data are scarce and derive mainly from European …
and quality of life. Global prevalence data are scarce and derive mainly from European …
Ventilation heterogeneity is associated with airway responsiveness in asthma but not COPD
KM Hardaker, SR Downie, JA Kermode… - Respiratory physiology …, 2013 - Elsevier
Airway hyperresponsiveness (AHR) occurs in both asthma and COPD. In older people with
asthma, AHR is associated with increased acinar ventilation heterogeneity, but it is unknown …
asthma, AHR is associated with increased acinar ventilation heterogeneity, but it is unknown …