The role of the small airways in the clinical expression of asthma in adults

…, SR Downie, JA Kermode, KM Hardaker… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: The clinical relevance of increased ventilation heterogeneity, a marker of
small-airways disease, in asthmatic patients is unclear. Ventilation heterogeneity is an …

Obesity is a determinant of asthma control independent of inflammation and lung mechanics

…, JA Kermode, SR Downie, NJ Brown, KM Hardaker… - Chest, 2011 - Elsevier
Background It is unclear why obesity is associated with worse asthma control. We hypothesized
that (1) obesity affects asthma control independent of spirometry, airway inflammation, …

Overdiagnosis of COPD in subjects with unobstructed spirometry: a BOLD analysis

…, C Jenkins, G Marks, T Bird, P Espinel, K Hardaker… - Chest, 2019 - Elsevier
Background There are several reports on underdiagnosis of COPD, while little is known
about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the …

[HTML][HTML] A systematic approach to multiple breath nitrogen washout test quality

…, C Saunders, PD Robinson, H Webster, K Hardaker… - PloS one, 2016 - journals.plos.org
Background Accurate estimates of multiple breath washout (MBW) outcomes require correct
operation of the device, appropriate distraction of the subject to ensure they breathe in a …

Predictors of airway hyperresponsiveness differ between old and young patients with asthma

KM Hardaker, SR Downie, JA Kermode, CS Farah… - Chest, 2011 - Elsevier
Background Age-related increases in morbidity and mortality due to asthma may be due to
changes in pathophysiology as patients with asthma get older. There is limited knowledge …

Association between peripheral airway function and neutrophilic inflammation in asthma

CS Farah, LAB Keulers, KM Hardaker, MJ Peters… - …, 2015 - Wiley Online Library
Background and objective Small airway dysfunction is associated with asthma severity and
control, but its association with airway inflammation is unknown. The aim was to determine …

Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts

…, VE Murphy, PD Robinson, K Jesson, K Hardaker… - Thorax, 2021 - thorax.bmj.com
Rationale Asthma in pregnancy is associated with respiratory diseases in the offspring.
Objective To investigate if maternal asthma is associated with lung function in early life. Methods …

Home-based forced oscillation technique day-to-day variability in pediatric asthma

A Wong, K Hardaker, P Field… - American Journal of …, 2019 - atsjournals.org
Methods Enrollment for this study targeted children 8–18 years of age with physician-diagnosed
persistent asthma and two or more exacerbations in the preceding 12 months. After …

[HTML][HTML] Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross …

…, G Marks, T Bird, P Espinel, K Hardaker… - …, 2024 - thelancet.com
Background Chronic cough is a common respiratory symptom with an impact on daily activities
and quality of life. Global prevalence data are scarce and derive mainly from European …

Ventilation heterogeneity is associated with airway responsiveness in asthma but not COPD

KM Hardaker, SR Downie, JA Kermode… - Respiratory physiology …, 2013 - Elsevier
Airway hyperresponsiveness (AHR) occurs in both asthma and COPD. In older people with
asthma, AHR is associated with increased acinar ventilation heterogeneity, but it is unknown …