Bronchial thermoplasty induced airway smooth muscle reduction and clinical response in severe asthma. The TASMA randomized trial

…, JNS d'Hooghe, K Srikanthan… - American journal of …, 2021 - atsjournals.org
Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma
targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction …

Safety and adverse events after targeted lung denervation for symptomatic moderate to severe chronic obstructive pulmonary disease (AIRFLOW). A multicenter …

…, R Gosens, JE Hartman, K Srikanthan… - American Journal of …, 2019 - atsjournals.org
Rationale: Targeted lung denervation (TLD) is a bronchoscopic radiofrequency ablation
therapy for chronic obstructive pulmonary disease (COPD), which durably disrupts …

Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD

…, L Finney, N Tirlapur, K Srikanthan… - … of Physiology-Lung …, 2021 - journals.physiology.org
Despite advances in the pathophysiology of chronic obstructive pulmonary disease (COPD),
there is a distinct lack of biochemical markers to aid clinical management. Microvesicles (…

Symptomatic, biochemical and radiographic recovery in patients with COVID-19

…, B Russell, J Chen, K Srikanthan… - BMJ open …, 2021 - bmjopenrespres.bmj.com
Background The symptoms, radiography, biochemistry and healthcare utilisation of patients
with COVID-19 following discharge from hospital have not been well described. Methods …

[HTML][HTML] Bronchoscopic targeted lung denervation in patients with severe asthma: preliminary findings

JE Hartman, K Srikanthan, C Caneja, NHT Ten Hacken… - Respiration, 2022 - karger.com
Abstract Treatment options for severe asthma are limited, particularly in those patients who
do not meet criteria for biologicals. Targeted lung denervation (TLD) is the bronchoscopic …

5-year survival after endobronchial coil implantation: secondary analysis of the first randomised controlled trial, RESET

JL Garner, SV Kemp, K Srikanthan, C Caneja… - Respiration, 2020 - karger.com
Background: Lung volume reduction surgery is a proven treatment for emphysematous patients
with hyperinflation, but the precarious health of candidates has prompted development …

Targeted lung denervation modulates the mucosal epithelial transcriptome in COPD

K Srikanthan, L Kistemaker, DJ Slebos… - ERJ open …, 2022 - Eur Respiratory Soc
Targeted lung denervation (TLD) is a novel treatment for COPD with evidence of a potential
beneficial effect on exacerbation frequency [1]. It is a minimally invasive procedure involving …

[HTML][HTML] Computed tomographic airway morphology after targeted lung denervation treatment in COPD

…, H Mal, Y Costa, PL Shah, J Garner, K Srikanthan… - Respiratory …, 2023 - Elsevier
This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters
after targeted lung denervation (TLD) and whether these changes are associated with …

[HTML][HTML] Recovering from COVID-19: lessons learnt from an intensive secondary care follow-up service

…, P Ricci, M Al-Zubaidy, K Srikanthan… - Future Healthcare …, 2022 - ncbi.nlm.nih.gov
In response to the first COVID-19 surge in 2020, secondary care outpatient services were
rapidly reconfigured to provide specialist review for disease sequelae. At our institution, …

Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) versus flexible 19G endobronchial ultrasound transbronchial needle (Flex 19G EBUS-TBNA …

…, A Rice, S Crichton, JL Garner, K Srikanthan… - 2019 - Eur Respiratory Soc
Background: Endobronchial Ultrasound guidance allows lymph nodes in the mediastinum
to be sampled under direct vision. The currently available EBUS-TBNA needles usually …