Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

…, G Christensen, KO Larsen… - … of Physiology-Lung …, 2015 - journals.physiology.org
Pulmonary hypertension is a serious condition that can lead to premature death. The
mechanisms involved are incompletely understood although a role for the immune system has …

Elevated levels of activin A in clinical and experimental pulmonary hypertension

A Yndestad, KO Larsen, E Øie… - Journal of applied …, 2009 - journals.physiology.org
Activin A, a member of the transforming growth factor (TGF)-β superfamily, is involved in
regulation of tissue remodeling and inflammation. Herein, we wanted to explore a role for activin …

Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension

…, OH Skjønsberg, KO Larsen - … of Physiology-Lung …, 2019 - journals.physiology.org
Lung diseases with hypoxia are complicated by pulmonary hypertension, leading to heart
failure and death. No pharmacological treatment exists. Increased proinflammatory cytokines …

Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice

KO Larsen, I Sjaastad, A Svindland… - American Journal …, 2006 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) may lead to pulmonary hypertension (PH)
and reduced function of the right ventricle (RV). However, COPD patients may also develop …

Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation

KO Larsen, A Yndestad, I Sjaastad… - … of Physiology-Lung …, 2011 - journals.physiology.org
The chemokine receptor CCR7 regulates lymphocyte trafficking, and CCR7 deficiency induces
infiltration of T and B cells adjacent to vessels in mouse lungs. Perivascular infiltration of …

Thromboembolic events after high‐intensity training during cisplatin‐based chemotherapy for testicular cancer: case reports and review of the literature

…, GM Gjerset, E Edvardsen, KO Larsen… - … Journal of Cancer, 2020 - Wiley Online Library
The randomized “Testicular cancer and Aerobic and Strength Training trial” (TAST‐trial) aimed
to evaluate the effect of high‐intensity interval training (HIIT) on cardiorespiratory fitness …

Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A

KO Larsen, B Lygren, I Sjaastad… - Cardiovascular …, 2008 - academic.oup.com
Aims Chronic obstructive pulmonary disease with alveolar hypoxia is associated with diastolic
dysfunction in the right and left ventricle (LV). LV diastolic dysfunction is not caused by …

IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung

…, EM Løberg, G Christensen, KO Larsen… - Experimental Lung …, 2012 - Taylor & Francis
Interleukin (IL)-18 is a pro-inflammatory cytokine suggested to be involved in the development
of pulmonary emphysema and inflammation. Studies involving immunology and cancer …

Thromboembolic events after high-intensity training during cisplatin-based chemotherapy for testicular cancer.

…, T Wisloff, E Edvardsen, GM Gjerset, KO Larsen… - 2017 - ascopubs.org
4551 Background: Physical activity (PA) is believed to reduce acute side-effects as deconditioning,
fatigue and nausea during chemotherapy and enhance post-treatment physical and …

Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers

…, G Christensen, OH Skjønsberg, KO Larsen… - Physiological …, 2022 - Wiley Online Library
Mountain climbing at high altitude implies exposure to low levels of oxygen, low temperature,
wind, physical and psychological stress, and nutritional insufficiencies. We examined …