[HTML][HTML] Fatty Acid Transduction of Nitric Oxide Signaling: MULTIPLE NITRATED UNSATURATED FATTY ACID DERIVATIVES EXIST IN HUMAN BLOOD AND URINE …

…, C Batthyany, S Sweeney, MH Long, KE Iles… - Journal of Biological …, 2005 - ASBMB
Mass spectrometric analysis of human plasma and urine revealed abundant nitrated
derivatives of all principal unsaturated fatty acids. Nitrated palmitoleic, oleic, linoleic, linolenic, …

Macrophage signaling and respiratory burst

KE Iles, HJ Forman - Immunologic research, 2002 - Springer
Macrophages are key defenders of the lung and play an essential role in mediating the
inflammatory response. Critical to this is the activation of the NADPH oxidase. Through receptor-…

Curcumin alters EpRE and AP‐1 binding complexes and elevates glutamate‐cysteine ligase gene expression

DA Dickinson, KE Iles, H Zhang, V Blank… - The FASEB …, 2003 - Wiley Online Library
Dietary use of curcumin, the active component of tumeric, one of the most widely used
spices, is linked to several beneficial health effects, although the underlying molecular …

Cytoprotection against oxidative stress and the regulation of glutathione synthesis

DA Dickinson, DR Moellering, KE Iles, RP Patel… - 2003 - degruyter.com
Adaptation to oxidative and nitrosative stress occurs in cells first exposed to a nontoxic
stress, resulting in the ability to tolerate a toxic challenge of the same or a related oxidant. …

Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress

DM Krzywanski, DA Dickinson, KE Iles… - Archives of biochemistry …, 2004 - Elsevier
Glutamate cysteine ligase (GCL), composed of a catalytic (GCLC) and modulatory (GCLM)
subunit, catalyzes the first step of glutathione (GSH) biosynthesis. Using 4-hydroxy-2-nonenal …

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression

…, P Powell, P Chumley, KE Iles… - Proceedings of the …, 2006 - National Acad Sciences
Nitroalkenes are a class of cell signaling mediators generated by NO and fatty acid-dependent
redox reactions. Nitrated fatty acids such as 10- and 12-nitro-9,12-octadecadienoic acid (…

[HTML][HTML] Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

A Lazrak, KE Iles, G Liu, DL Noah, JW Noah… - The FASEB …, 2009 - ncbi.nlm.nih.gov
The mechanisms by which replicating influenza viruses decrease the expression and function
of amiloride-sensitive epithelial sodium channels (ENaCs) have not been elucidated. We …

HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells

KE Iles, DA Dickinson, AF Wigley, NE Welty… - Free Radical Biology …, 2005 - Elsevier
Heme oxygenase-1 (HO-1) is a key cytoprotective enzyme and an established marker of
oxidative stress. Increased HO-1 expression has been found in the resident macrophages in the …

Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter

PK Vayalil, KE Iles, J Choi, AK Yi… - … of Physiology-Lung …, 2007 - journals.physiology.org
Transforming growth factor (TGF)-β upregulates plasminogen activator inhibitor type 1 (PAI-1)
in a variety of cell types, and PAI-1 is considered to be an essential factor for the …

4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells

DA Dickinson, KE Iles, N Watanabe, T Iwamoto… - Free Radical Biology …, 2002 - Elsevier
Glutathione is the most abundant non-protein thiol in the cell, with roles in cell cycle regulation,
detoxification of xenobiotics, and maintaining the redox tone of the cell. The glutathione …