User profiles for K.R. Stenmark

Kurt R. Stenmark

La Cache Endowed Professor of Pediatrics and Medicine, University of Colorado Denver
Verified email at ucdenver.edu
Cited by 34411

Cellular and molecular pathobiology of pulmonary arterial hypertension

…, NW Morrell, SL Archer, KR Stenmark… - Journal of the American …, 2004 - jacc.org
Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction,
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms

KR Stenmark, KA Fagan, MG Frid - Circulation research, 2006 - Am Heart Assoc
Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well
as in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Cellular and molecular basis of pulmonary arterial hypertension

…, MR MacLean, IF McMurtry, KR Stenmark… - Journal of the American …, 2009 - jacc.org
Stenmark … Adnot and Stenmark report no conflicts of interest. … Stenmark KR, Davie N.,
Frid M., Gerasimovskaya E., Das M. "Role of the adventitia in pulmonary vascular remodeling". …

Pediatric pulmonary hypertension: guidelines from the American heart association and American thoracic society

…, EB Rosenzweig, JU Raj, D Cornfield, KR Stenmark… - Circulation, 2015 - Am Heart Assoc
Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

KR Stenmark, B Meyrick, N Galie… - … of Physiology-Lung …, 2009 - journals.physiology.org
… (KR Stenmark, unpublished observations), a finding that is also true for the hypoxic rat and
mouse models. It should also be noted that people who develop significant PH at altitude, so-…

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

…, RT Schermuly, KR Stenmark… - European …, 2019 - Eur Respiratory Soc
… Conflict of interest: KR Stenmark reports grants from ContraFect, personal fees for advisory
board work from Pfizer, New York, personal fees for membership of a steering Committee …

Inflammation, growth factors, and pulmonary vascular remodeling

…, M Rabinovitch, R Schermuly, KR Stenmark… - Journal of the american …, 2009 - jacc.org
Inflammatory processes are prominent in various types of human and experimental pulmonary
hypertension (PH) and are increasingly recognized as major pathogenic components of …

Relevant issues in the pathology and pathobiology of pulmonary hypertension

…, M Rabinovitch, R Schermuly, KR Stenmark… - Journal of the American …, 2013 - jacc.org
Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …

Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

…, JC Cambier, KR Stenmark… - Proceedings of the …, 2012 - National Acad Sciences
Recent studies have demonstrated dramatic shifts in metabolic supply-and-demand ratios
during inflammation, a process resulting in localized tissue hypoxia within inflammatory …

Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis

MG Frid, VA Kale, KR Stenmark - Circulation research, 2002 - Am Heart Assoc
Though in the past believed to be a rare phenomenon, endothelial-mesenchymal
transdifferentiation has been described with increasing frequency in recent years. It is believed to be …